onr:"swepub:oai:gup.ub.gu.se/224167"
Search: onr:"swepub:oai:gup.ub.gu.se/224167" > Chemokine Ligand 20...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Al-Alem, Linah (author)
Chemokine Ligand 20: A Signal for Leukocyte Recruitment During Human Ovulation?
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015-06-30
- The Endocrine Society,2015
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/224167
- https://gup.ub.gu.se/publication/224167URI
- https://doi.org/10.1210/en.2014-1874DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Ovulation is one of the cornerstones of female fertility. Disruption of the ovulatory process results in infertility, which affects approximately 10% of couples. Using a unique model in which the dominant follicle is collected across the periovulatory period in women, we have identified a leukocyte chemoattractant, chemokine ligand 20 (CCL20), in the human ovary. CCL20 mRNA is massively induced after an in vivo human chorionic gonadotropin (hCG) stimulus in granulosa (>10 000-fold) and theca (>4000-fold) cells collected during the early ovulatory (12-18 h) and late ovulatory (18-34 h) periods after hCG administration. Because the LH surge sets in motion an inflammatory reaction characterized by an influx of leukocytes and CCL20 is known to recruit leukocytes in other systems, the composition of ovarian leukocytes (CD45+) containing the CCL20 receptor CCR6 was determined immediately prior to ovulation. CD45+/CCR6+ cells were primarily natural killer cells (41%) along with B cells (12%), T cells (11%), neutrophils (10%), and monocytes (9%). Importantly, exogenous CCL20 stimulated ovarian leukocyte migration 59% within 90 minutes. Due to the difficulties in obtaining human follicles, an in vitro model was developed using granulosa-lutein cells to explore CCL20 regulation. CCL20 expression increased 40-fold within 6 hours after hCG, was regulated partially by the epithelial growth factor pathway, and was positively correlated with progesterone production. These results demonstrate that hCG dramatically increases CCL20 expression in the human ovary, that ovarian leukocytes contain the CCL20 receptor, and that CCL20 stimulates leukocyte migration. Our findings raise the prospect that CCL20 may aid in the final ovulatory events and contribute to fertility in women.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Puttabyatappa, Muraly (author)
- Rosewell, Kathy (author)
- Brännström, Mats,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xbrmat (author)
- Akin, James (author)
- Boldt, Jeffrey (author)
- Muse, Ken (author)
- Curry, Thomas E (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)
Related titles
- In:Endocrinology: The Endocrine Society156:9, s. 3358-691945-71700013-7227
Internet link
Find in a library
- Endocrinology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Al-Alem, Linah
- Puttabyatappa, M ...
- Rosewell, Kathy
- Brännström, Mats ...
- Akin, James
- Boldt, Jeffrey
- show more...
- Muse, Ken
- Curry, Thomas E
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Endocrinology
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
