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Polymorphisms in Ge...
Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium
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Lagergren, K. (author)
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Ek, Weronica E (author)
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Levine, D. (author)
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Chow, W. H. (author)
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Bernstein, L. (author)
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Casson, A. G. (author)
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Risch, H. A. (author)
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Shaheen, N. J. (author)
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Bird, N. C. (author)
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Reid, B. J. (author)
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Corley, D. A. (author)
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- Hardie, L. J. (author)
- Karolinska Institutet
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Wu, A. H. (author)
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Fitzgerald, R. C. (author)
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Pharoah, P. (author)
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Caldas, C. (author)
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Romero, Y. (author)
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Vaughan, T. L. (author)
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MacGregor, S. (author)
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Whiteman, D. (author)
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- Westberg, Lars, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Nyren, O. (author)
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Lagergren, J. (author)
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(creator_code:org_t)
- 2015-09-25
- 2015
- English.
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In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 10:9
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Abstract
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- Background The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett's oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or oxytocin, might contribute. This genetic-epidemiological study pooled 14 studies from three continents, Australia, Europe, and North America. Polymorphisms in 3 key genes coding for the oestrogen pathway (receptor alpha (ESR1), receptor beta (ESR2), and aromatase (CYP19A1)), and 3 key genes of the oxytocin pathway (the oxytocin receptor (OXTR), oxytocin protein (OXT), and cyclic ADP ribose hydrolase glycoprotein (CD38)), were analysed using a gene-based approach, versatile gene-based test association study (VEGAS). Among 1508 OAC patients, 2383 BO patients, and 2170 controls, genetic variants within ESR1 were associated with BO in males (p = 0.0058) and an increased risk of OAC and BO combined in males (p = 0.0023). Genetic variants within OXTR were associated with an increased risk of BO in both sexes combined (p = 0.0035) and in males (p = 0.0012). We followed up these suggestive findings in a further smaller data set, but found no replication. There were no significant associations between the other 4 genes studied and risk of OAC, BO, separately on in combination, in males and females combined or in males only. Genetic variants in the oestrogen receptor alpha and the oxytocin receptor may be associated with an increased risk of BO or OAC, but replication in other large samples are needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- genome-wide association
- gastroesophageal-reflux
- receptor gene
- postmenopausal women
- social-behavior
- esr1 gene
- cancer
- carcinoma
- proliferation
- variability
- Science & Technology - Other Topics
- netics
- v153b
- p1391
Publication and Content Type
- ref (subject category)
- art (subject category)
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Plos One
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To the university's database
- By the author/editor
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Lagergren, K.
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Ek, Weronica E
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Levine, D.
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Chow, W. H.
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Bernstein, L.
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Casson, A. G.
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show more...
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Risch, H. A.
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Shaheen, N. J.
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Bird, N. C.
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Reid, B. J.
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Corley, D. A.
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Hardie, L. J.
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Wu, A. H.
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Fitzgerald, R. C ...
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Pharoah, P.
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Caldas, C.
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Romero, Y.
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Vaughan, T. L.
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MacGregor, S.
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Whiteman, D.
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Westberg, Lars, ...
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Nyren, O.
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Lagergren, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Plos One
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet