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Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline

Lista, S. (author)
Molinuevo, J. L. (author)
Cavedo, E. (author)
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Rami, L. (author)
Amouyel, P. (author)
Teipel, S. J. (author)
Garaci, F. (author)
Toschi, N. (author)
Habert, M. O. (author)
Blennow, Kaj, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Zetterberg, Henrik, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
O'Bryant, S. E. (author)
Johnson, L. (author)
Galluzzi, S. (author)
Bokde, A. L. W. (author)
Broich, K. (author)
Herholz, K. (author)
Bakardjian, H. (author)
Dubois, B. (author)
Jessen, F. (author)
Carrillo, M. C. (author)
Aisen, P. S. (author)
Hampel, H. (author)
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 (creator_code:org_t)
IOS Press, 2015
2015
English.
In: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 48
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • There is evolving evidence that individuals categorized with subjective cognitive decline (SCD) are potentially at higher risk for developing objective and progressive cognitive impairment compared to cognitively healthy individuals without apparent subjective complaints. Interestingly, SCD, during advancing preclinical Alzheimer's disease (AD), may denote very early, subtle cognitive decline that cannot be identified using established standardized tests of cognitive performance. The substantial heterogeneity of existing SCD-related research data has led the Subjective Cognitive Decline Initiative (SCD-I) to accomplish an international consensus on the definition of a conceptual research framework on SCD in preclinical AD. In the area of biological markers, the cerebrospinal fluid signature of AD has been reported to be more prevalent in subjects with SCD compared to healthy controls; moreover, there is a pronounced atrophy, as demonstrated by magnetic resonance imaging, and an increased hypometabolism, as revealed by positron emission tomography, in characteristic brain regions affected by AD. In addition, SCD individuals carrying an apolipoprotein epsilon 4 allele are more likely to display AD-phenotypic alterations. The urgent requirement to detect and diagnose AD as early as possible has led to the critical examination of the diagnostic power of biological markers, neurophysiology, and neuroimaging methods for AD-related risk and clinical progression in individuals defined with SCD. Observational studies on the predictive value of SCD for developing AD may potentially be of practical value, and an evidence-based, validated, qualified, and fully operationalized concept may inform clinical diagnostic practice and guide earlier designs in future therapy trials.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Alzheimer's disease
biological markers
blood-based biomarkers
cerebrospinal fluid biomarkers
beta-amyloid 1-42
alzheimers association workgroups
transcranial
magnetic stimulation
cerebrospinal-fluid biomarkers
white-matter
hyperintensities
heterogeneous brain-tissue
gaussian water diffusion
blood-based biomarkers
temporal-lobe atrophy
pittsburgh-compound-b
Neurosciences & Neurology
C 02-04
2007
Las Vegas
NV
V4
PS98

Publication and Content Type

ref (subject category)
art (subject category)

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