Search: onr:"swepub:oai:gup.ub.gu.se/224887" >
Interaction between...
Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis
-
Hangen, Emilie (author)
-
Féraud, Olivier (author)
-
Lachkar, Sylvie (author)
-
show more...
-
Mou, Haiwei (author)
-
Doti, Nunzianna (author)
-
Fimia, Gian Maria (author)
-
Lam, Ngoc-Vy (author)
-
- Zhu, Changlian, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
Godin, Isabelle (author)
-
Muller, Kevin (author)
-
Chatzi, Afroditi (author)
-
Nuebel, Esther (author)
-
Ciccosanti, Fabiola (author)
-
Flamant, Stéphane (author)
-
Bénit, Paule (author)
-
Perfettini, Jean-Luc (author)
-
Sauvat, Allan (author)
-
Bennaceur-Griscelli, Annelise (author)
-
Ser-Le Roux, Karine (author)
-
Gonin, Patrick (author)
-
Tokatlidis, Kostas (author)
-
Rustin, Pierre (author)
-
Piacentini, Mauro (author)
-
Ruvo, Menotti (author)
-
- Blomgren, Klas, 1963 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
Kroemer, Guido (author)
-
Modjtahedi, Nazanine (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
-
In: Molecular cell. - : Elsevier BV. - 1097-4164 .- 1097-2765. ; 58:6, s. 1001-1014
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory chain complexes. Here we identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery. Depletion or hypomorphic mutation of AIF caused a downregulation of CHCHD4 protein by diminishing its mitochondrial import. CHCHD4 depletion sufficed to induce a respiratory defect that mimicked that observed in AIF-deficient cells. CHCHD4 levels could be restored in AIF-deficient cells by enforcing its AIF-independent mitochondrial localization. This modified CHCHD4 protein reestablished respiratory function in AIF-deficient cells and enabled AIF-deficient embryoid bodies to undergo cavitation, a process of programmed cell death required for embryonic morphogenesis. These findings explain how AIF contributes to the biogenesis of respiratory chain complexes, and they establish an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Amino Acid Sequence
- Animals
- Apoptosis Inducing Factor
- genetics
- metabolism
- Cell Line
- Tumor
- Electron Transport
- genetics
- Electron Transport Chain Complex Proteins
- genetics
- metabolism
- Embryo
- Mammalian
- embryology
- metabolism
- Embryonic Development
- genetics
- Humans
- Immunoblotting
- Mice
- Knockout
- Mitochondria
- genetics
- metabolism
- Mitochondrial Membrane Transport Proteins
- genetics
- metabolism
- Molecular Sequence Data
- Protein Binding
- Protein Transport
- genetics
- RNA Interference
- Time Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Hangen, Emilie
-
Féraud, Olivier
-
Lachkar, Sylvie
-
Mou, Haiwei
-
Doti, Nunzianna
-
Fimia, Gian Mari ...
-
show more...
-
Lam, Ngoc-Vy
-
Zhu, Changlian, ...
-
Godin, Isabelle
-
Muller, Kevin
-
Chatzi, Afroditi
-
Nuebel, Esther
-
Ciccosanti, Fabi ...
-
Flamant, Stéphan ...
-
Bénit, Paule
-
Perfettini, Jean ...
-
Sauvat, Allan
-
Bennaceur-Grisce ...
-
Ser-Le Roux, Kar ...
-
Gonin, Patrick
-
Tokatlidis, Kost ...
-
Rustin, Pierre
-
Piacentini, Maur ...
-
Ruvo, Menotti
-
Blomgren, Klas, ...
-
Kroemer, Guido
-
Modjtahedi, Naza ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
- Articles in the publication
-
Molecular cell
- By the university
-
University of Gothenburg
-
Karolinska Institutet