onr:"swepub:oai:gup.ub.gu.se/225388"
Search: onr:"swepub:oai:gup.ub.gu.se/225388" > Efficacy and safety...
- 1 of 1
- Previous record
- Next record
- To hitlist
Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF
- Jhund, P. S. (author)
- Fu, M. (author)
- Bayram, E. (author)
- show more...
- Chen, C. H. (author)
- Negrusz-Kawecka, M. (author)
- Rosenthal, A. (author)
- Desai, A. S. (author)
- Lefkowitz, M. P. (author)
- Rizkala, A. R. (author)
- Rouleau, J. L. (author)
- Shi, V. C. (author)
- Solomon, S. D. (author)
- Zile, M. R. (author)
- McMurray, J. J. V. (author)
- Packer, M. (author)
- show less...
- (creator_code:org_t)
- 2015-07-31
- 2015
- English.
- In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 36:38, s. 2576-2584
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background The age at which heart failure develops varies widely between countries and drug tolerance and outcomes also vary by age. We have examined the efficacy and safety of LCZ696 according to age in the Prospective comparison of angiotensin receptor neprilysin inhibitor with angiotensin converting enzyme inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure trial (PARADIGM-HF). Methods In PARADIGM-HF, 8399 patients aged 18-96 years and in New York Heart Association functional class II-IV with an LVEF <= 40% were randomized to either enalapril or LCZ696. We examined the pre-specified efficacy and safety outcomes according to age category (years): <55 (n = 1624), 55-64 (n = 2655), 65-74 (n = 2557), and >= 75 (n = 1563). Findings The rate (per 100 patient-years) of the primary outcome of cardiovascular (CV) death or heart failure hospitalization (HFH) increased from 13.4 to 14.8 across the age categories. The LCZ696: enalapril hazard ratio (HR) was <1.0 in all categories (P for interaction between age category and treatment = 0.94) with an overall HR of 0.80 (0.73, 0.87), P < 0.001. The findings for HFH were similar for CV and all-cause mortality and the age category by treatment interactions were not significant. The pre-specified safety outcomes of hypotension, renal impairment and hyperkalaemia increased in both treatment groups with age, although the differences between treatment (more hypotension but less renal impairment and hyperkalaemia with LCZ696) were consistent across age categories. Interpretation LCZ696 was more beneficial than enalapril across the spectrum of age in PARADIGM-HF with a favourable benefit-risk profile in all age groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Heart failure
- Neprilysin
- Receptors
- Angiotensin
- Age
- systolic heart-failure
- clinical-trials
- neprilysin inhibition
- enalapril
- comorbidities
- management
- mortality
- program
- risk
- Cardiovascular System & Cardiology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- European Heart Journal (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Jhund, P. S.
- Fu, M.
- Bayram, E.
- Chen, C. H.
- Negrusz-Kawecka, ...
- Rosenthal, A.
- show more...
- Desai, A. S.
- Lefkowitz, M. P.
- Rizkala, A. R.
- Rouleau, J. L.
- Shi, V. C.
- Solomon, S. D.
- Swedberg, Karl, ...
- Zile, M. R.
- McMurray, J. J. ...
- Packer, M.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- European Heart J ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
