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Ruxolitinib in cort...
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
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Zeiser, R. (author)
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Burchert, A. (author)
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Lengerke, C. (author)
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show more...
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Verbeek, M. (author)
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Maas-Bauer, K. (author)
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Metzelder, S. K. (author)
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Spoerl, S. (author)
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Ditschkowski, M. (author)
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Ecsedi, M. (author)
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Sockel, K. (author)
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Ayuk, F. (author)
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Ajib, S. (author)
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de Fontbrune, F. S. (author)
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Na, I. K. (author)
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Penter, L. (author)
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Holtick, U. (author)
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Wolf, D. (author)
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Schuler, E. (author)
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Meyer, E. (author)
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Apostolova, P. (author)
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Bertz, H. (author)
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Marks, R. (author)
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Lubbert, M. (author)
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Wasch, R. (author)
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Scheid, C. (author)
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Stolzel, F. (author)
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Ordemann, R. (author)
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Bug, G. (author)
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Kobbe, G. (author)
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Negrin, R. (author)
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- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Spyridonidis, A. (author)
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Schmitt-Graff, A. (author)
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van der Velden, W. (author)
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Huls, G. (author)
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Mielke, S. (author)
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Grigoleit, G. U. (author)
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Kuball, J. (author)
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Flynn, R. (author)
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Ihorst, G. (author)
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Du, J. (author)
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Blazar, B. R. (author)
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Arnold, R. (author)
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Kroger, N. (author)
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Passweg, J. (author)
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Halter, J. (author)
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Socie, G. (author)
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Beelen, D. (author)
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Peschel, C. (author)
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Neubauer, A. (author)
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Finke, J. (author)
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Duyster, J. (author)
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von Bubnoff, N. (author)
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(creator_code:org_t)
- 2015-07-31
- 2015
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 29:10, s. 2062-2068
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Despite major improvements in allogeneic hematopoietic cell transplantation over the past decades, corticosteroid-refractory (SR) acute (a) and chronic (c) graft-versus-host disease (GVHD) cause high mortality. Preclinical evidence indicates the potent anti-inflammatory properties of the JAK1/2 inhibitor ruxolitinib. In this retrospective survey, 19 stem cell transplant centers in Europe and the United States reported outcome data from 95 patients who had received ruxolitinib as salvage therapy for SR-GVHD. Patients were classified as having SR-aGVHD (n = 54, all grades III or IV) or SR-cGVHD (n = 41, all moderate or severe). The median number of previous GVHD-therapies was 3 for both SR-aGVHD (1-7) and SR-cGVHD (1-10). The overall response rate was 81.5% (44/54) in SR-aGVHD including 25 complete responses (46.3%), while for SR-cGVHD the ORR was 85.4% (35/41). Of those patients responding to ruxolitinib, the rate of GVHD-relapse was 6.8% (3/44) and 5.7% (2/35) for SR-aGVHD and SR-cGVHD, respectively. The 6-month-survival was 79% (67.3-90.7%, 95% confidence interval (CI)) and 97.4% (92.3-100%, 95% CI) for SR-aGVHD and SR-cGVHD, respectively. Cytopenia and cytomegalovirus-reactivation were observed during ruxolitinib treatment in both SR-aGVHD (30/54, 55.6% and 18/54, 33.3%) and SR-cGVHD (7/41, 17.1% and 6/41, 14.6%) patients. Ruxolitinib may constitute a promising new treatment option for SR-aGVHD and SR-cGVHD that should be validated in a prospective trial.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- ANTITHYMOCYTE GLOBULIN THERAPY
- ACUTE GVHD
- EXTRACORPOREAL
- PHOTOPHERESIS
- MYCOPHENOLATE-MOFETIL
- CYTOKINE INHIBITION
- SALVAGE
- THERAPY
- FACTOR-RECEPTOR
- RESISTANT
- ALEMTUZUMAB
- SURVIVAL
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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Leukemia
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Zeiser, R.
-
Burchert, A.
-
Lengerke, C.
-
Verbeek, M.
-
Maas-Bauer, K.
-
Metzelder, S. K.
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show more...
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Spoerl, S.
-
Ditschkowski, M.
-
Ecsedi, M.
-
Sockel, K.
-
Ayuk, F.
-
Ajib, S.
-
de Fontbrune, F. ...
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Na, I. K.
-
Penter, L.
-
Holtick, U.
-
Wolf, D.
-
Schuler, E.
-
Meyer, E.
-
Apostolova, P.
-
Bertz, H.
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Marks, R.
-
Lubbert, M.
-
Wasch, R.
-
Scheid, C.
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Stolzel, F.
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Ordemann, R.
-
Bug, G.
-
Kobbe, G.
-
Negrin, R.
-
Brune, Mats, 195 ...
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Spyridonidis, A.
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Schmitt-Graff, A ...
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van der Velden, ...
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Huls, G.
-
Mielke, S.
-
Grigoleit, G. U.
-
Kuball, J.
-
Flynn, R.
-
Ihorst, G.
-
Du, J.
-
Blazar, B. R.
-
Arnold, R.
-
Kroger, N.
-
Passweg, J.
-
Halter, J.
-
Socie, G.
-
Beelen, D.
-
Peschel, C.
-
Neubauer, A.
-
Finke, J.
-
Duyster, J.
-
von Bubnoff, N.
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia
- By the university
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University of Gothenburg