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A catalog of the mo...
A catalog of the mouse gut metagenome
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Xiao, L. (author)
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Feng, Q. (author)
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Liang, S. S. (author)
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show more...
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Sonne, S. B. (author)
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Xia, Z. K. (author)
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Qiu, X. M. (author)
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Li, X. P. (author)
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Long, H. (author)
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Zhang, J. F. (author)
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Zhang, D. Y. (author)
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Liu, C. (author)
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Fang, Z. W. (author)
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Chou, J. (author)
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Glanville, J. (author)
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Hao, Q. (author)
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Kotowska, D. (author)
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Colding, C. (author)
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Licht, T. R. (author)
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Wu, D. H. (author)
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Yu, J. (author)
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Sung, J. J. Y. (author)
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Liang, Q. Y. (author)
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Li, J. H. (author)
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Jia, H. J. (author)
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Lan, Z. (author)
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- Tremaroli, Valentina, 1978 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Dworzynski, P. (author)
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Nielsen, H. B. (author)
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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Dore, J. (author)
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Le Chatelier, E. (author)
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Ehrlich, S. D. (author)
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Lin, J. C. (author)
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Arumugam, M. (author)
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Wang, J. (author)
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Madsen, L. (author)
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Kristiansen, K. (author)
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(creator_code:org_t)
- 2015-09-28
- 2015
- English.
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In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 33:10
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Abstract
Subject headings
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- We established a catalog of the mouse gut metagenome comprising similar to 2.6 million nonredundant genes by sequencing DNA from fecal samples of 184 mice. To secure high microbiome diversity, we used mouse strains of diverse genetic backgrounds, from different providers, kept in different housing laboratories and fed either a low-fat or high-fat diet. Similar to the human gut microbiome, >99% of the cataloged genes are bacterial. We identified 541 metagenomic species and defined a core set of 26 metagenomic species found in 95% of the mice. The mouse gut microbiome is functionally similar to its human counterpart, with 95.2% of its Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologous groups in common. However, only 4.0% of the mouse gut microbial genes were shared (95% identity, 90% coverage) with those of the human gut microbiome. This catalog provides a useful reference for future studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- HIGH-FAT
- MICROBIOTA
- MICE
- OBESITY
- HOST
- DIET
- DISEASE
- GENES
- INFLAMMATION
- ENTEROTYPES
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Xiao, L.
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Feng, Q.
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Liang, S. S.
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Sonne, S. B.
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Xia, Z. K.
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Qiu, X. M.
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show more...
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Li, X. P.
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Long, H.
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Zhang, J. F.
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Zhang, D. Y.
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Liu, C.
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Fang, Z. W.
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Chou, J.
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Glanville, J.
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Hao, Q.
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Kotowska, D.
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Colding, C.
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Licht, T. R.
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Wu, D. H.
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Yu, J.
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Sung, J. J. Y.
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Liang, Q. Y.
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Li, J. H.
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Jia, H. J.
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Lan, Z.
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Tremaroli, Valen ...
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Dworzynski, P.
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Nielsen, H. B.
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Bäckhed, Fredrik ...
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Dore, J.
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Le Chatelier, E.
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Ehrlich, S. D.
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Lin, J. C.
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Arumugam, M.
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Wang, J.
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Madsen, L.
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Kristiansen, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Biotechno ...
- By the university
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University of Gothenburg