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Heparan sulfate and...
Heparan sulfate and heparin interactions with proteins
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Meneghetti, M. C. Z. (author)
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- Hughes, Ashley J, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Rudd, T. R. (author)
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Nader, H. B. (author)
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Powell, A. K. (author)
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Yates, E. A. (author)
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Lima, M. A. (author)
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(creator_code:org_t)
- 2015-09-06
- 2015
- English.
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In: Journal of the Royal Society Interface. - : The Royal Society. - 1742-5689 .- 1742-5662. ; 12:110
- Related links:
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https://royalsociety...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and extracellular matrix of all multicellular animals, whereas heparin is present within mast cells and can be viewed as a more sulfated, tissue-specific, HS variant. HS and heparin regulate biological processes through interactions with a large repertoire of proteins. Owing to these interactions and diverse effects observed during in vitro, ex vivo and in vivo experiments, manifold biological/pharmacological activities have been attributed to them. The properties that have been thought to bestow protein binding and biological activity upon HS and heparin vary from high levels of sequence specificity to a dependence on charge. In contrast to these opposing opinions, we will argue that the evidence supports both a level of redundancy and a degree of selectivity in the structure-activity relationship. The relationship between this apparent redundancy, the multi-dentate nature of heparin and HS polysaccharide chains, their involvement in protein networks and the multiple binding sites on proteins, each possessing different properties, will also be considered. Finally, the role of cations in modulating HS/heparin activity will be reviewed and some of the implications for structure-activity relationships and regulation will be discussed.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- heparin
- heparan sulfate
- polysaccharide
- protein binding
- redundancy
- cations
- FIBROBLAST-GROWTH-FACTOR
- ACTIVE PENTASACCHARIDE SEQUENCE
- MOLECULAR-WEIGHT HEPARIN
- FACTOR RECEPTOR COMPLEX
- HEPARIN/HEPARAN
- SULFATE
- STRUCTURAL-FEATURES
- MITOGENIC ACTIVITY
- CRYSTAL-STRUCTURE
- ANTITHROMBIN-III
- IONIC-STRENGTH
- Multidisciplinary Sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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