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COPD Patients Have ...
COPD Patients Have Short Lung Magnetic Resonance T1 Relaxation Time.
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- Alamidi, Daniel (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg
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- Morgan, Alexandra R (author)
- University of Manchester
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- Hubbard Cristinacce, Penny L (author)
- University of Manchester
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- Nordenmark, Lars H (author)
- AstraZeneca AB
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- Hockings, Paul, 1956 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lagerstrand, Kerstin M (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg
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- Young, Simon S (author)
- AstraZeneca AB
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- Naish, Josephine H (author)
- University of Manchester
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- Waterton, John C (author)
- University of Manchester
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Maguire, Niall C (author)
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- Olsson, Lars E (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups
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- Parker, Geoffrey J M (author)
- University of Manchester
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(creator_code:org_t)
- 2015-10-21
- 2016
- English.
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In: COPD. - : Informa UK Limited. - 1541-2563 .- 1541-2555. ; 13:2, s. 153-159
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Abstract
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- Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment of pulmonary disease in clinical trials as it is free from ionizing radiation, minimally invasive and allows regional information. The aim of this study was to characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive pulmonary disease (COPD); and specifically its relationship to smoking history, computed tomography (CT), and pulmonary function test (PFT) measurements in comparison to healthy age-matched controls. Lung T1 and inter-quartile range (IQR) of T1 maps from 24 COPD subjects and 12 healthy age-matched non-smokers were retrospectively analyzed from an institutional review board approved study. The subjects underwent PFTs and two separate MR imaging sessions at 1.5 tesla to test T1 repeatability. CT scans were performed on the COPD subjects. T1 repeatability (intraclass correlation coefficient) was 0.72 for repeated scans acquired on two visits. The lung T1 was significantly shorter (p < 0.0001) and T1 IQR was significantly larger (p = 0.0002) for the COPD subjects compared to healthy controls. Lung T1 significantly (p = 0.001) correlated with lung density assessed with CT. Strong significant correlations (p < 0.0001) between lung T1 and all PFT measurements were observed. Cigarette exposure did not correlate with lung T1 in COPD subjects. In conclusion, lung MRI T1 mapping shows potential as a repeatable, radiation free, non-invasive imaging technique in the evaluation of COPD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- biomarker
- chronic obstructive pulmonary disease (COPD)
- longitudinal relaxation time
- lung imaging
- magnetic resonance imaging (MRI)
- smoking
- biomarker
Publication and Content Type
- ref (subject category)
- art (subject category)
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COPD
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- By the author/editor
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Alamidi, Daniel
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Morgan, Alexandr ...
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Hubbard Cristina ...
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Nordenmark, Lars ...
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Hockings, Paul, ...
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Lagerstrand, Ker ...
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show more...
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Young, Simon S
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Naish, Josephine ...
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Waterton, John C
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Maguire, Niall C
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Olsson, Lars E
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Parker, Geoffrey ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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COPD
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COPD: Journal of ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Lund University