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  • Alamidi, DanielGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg (author)

COPD Patients Have Short Lung Magnetic Resonance T1 Relaxation Time.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2015-10-21
  • Informa UK Limited,2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/227079
  • https://gup.ub.gu.se/publication/227079URI
  • https://doi.org/10.3109/15412555.2015.1048851DOI
  • https://research.chalmers.se/publication/227079URI
  • https://lup.lub.lu.se/record/8148735URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment of pulmonary disease in clinical trials as it is free from ionizing radiation, minimally invasive and allows regional information. The aim of this study was to characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive pulmonary disease (COPD); and specifically its relationship to smoking history, computed tomography (CT), and pulmonary function test (PFT) measurements in comparison to healthy age-matched controls. Lung T1 and inter-quartile range (IQR) of T1 maps from 24 COPD subjects and 12 healthy age-matched non-smokers were retrospectively analyzed from an institutional review board approved study. The subjects underwent PFTs and two separate MR imaging sessions at 1.5 tesla to test T1 repeatability. CT scans were performed on the COPD subjects. T1 repeatability (intraclass correlation coefficient) was 0.72 for repeated scans acquired on two visits. The lung T1 was significantly shorter (p < 0.0001) and T1 IQR was significantly larger (p = 0.0002) for the COPD subjects compared to healthy controls. Lung T1 significantly (p = 0.001) correlated with lung density assessed with CT. Strong significant correlations (p < 0.0001) between lung T1 and all PFT measurements were observed. Cigarette exposure did not correlate with lung T1 in COPD subjects. In conclusion, lung MRI T1 mapping shows potential as a repeatable, radiation free, non-invasive imaging technique in the evaluation of COPD.

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  • Morgan, Alexandra RUniversity of Manchester (author)
  • Hubbard Cristinacce, Penny LUniversity of Manchester (author)
  • Nordenmark, Lars HAstraZeneca AB (author)
  • Hockings, Paul,1956Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)hockings (author)
  • Lagerstrand, Kerstin MGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg(Swepub:gu)xlagke (author)
  • Young, Simon SAstraZeneca AB (author)
  • Naish, Josephine HUniversity of Manchester (author)
  • Waterton, John CUniversity of Manchester (author)
  • Maguire, Niall C (author)
  • Olsson, Lars ELund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)rfa-lol (author)
  • Parker, Geoffrey J MUniversity of Manchester (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för radiofysik (creator_code:org_t)

Related titles

  • In:COPD: Informa UK Limited13:2, s. 153-1591541-25631541-2555
  • In:COPD: Journal of Chronic Obstructive Pulmonary Disease: Informa UK Limited13:2, s. 153-1591541-2555

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