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Cardiorespiratory F...
Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition.
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Schultz, Stephanie A (author)
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Boots, Elizabeth A (author)
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Almeida, Rodrigo P (author)
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Oh, Jennifer M (author)
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Einerson, Jean (author)
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Korcarz, Claudia E (author)
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Edwards, Dorothy F (author)
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Koscik, Rebecca L (author)
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Dowling, Maritza N (author)
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Gallagher, Catherine L (author)
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Bendlin, Barbara B (author)
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Christian, Bradley T (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Carlsson, Cynthia M (author)
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Asthana, Sanjay (author)
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Hermann, Bruce P (author)
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Sager, Mark A (author)
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Johnson, Sterling C (author)
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Stein, James H (author)
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Okonkwo, Ozioma C (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Journal of the International Neuropsychological Society : JINS. - 1469-7661. ; 21:10, s. 841-50
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Abstract
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- The aim of this study was to examine cross-sectionally whether higher cardiorespiratory fitness (CRF) might favorably modify amyloid-β (Aβ)-related decrements in cognition in a cohort of late-middle-aged adults at risk for Alzheimer's disease (AD). Sixty-nine enrollees in the Wisconsin Registry for Alzheimer's Prevention participated in this study. They completed a comprehensive neuropsychological exam, underwent 11C Pittsburgh Compound B (PiB)-PET imaging, and performed a graded treadmill exercise test to volitional exhaustion. Peak oxygen consumption (VO2peak) during the exercise test was used as the index of CRF. Forty-five participants also underwent lumbar puncture for collection of cerebrospinal fluid (CSF) samples, from which Aβ42 was immunoassayed. Covariate-adjusted regression analyses were used to test whether the association between Aβ and cognition was modified by CRF. There were significant VO2peak*PiB-PET interactions for Immediate Memory (p=.041) and Verbal Learning & Memory (p=.025). There were also significant VO2peak*CSF Aβ42 interactions for Immediate Memory (p<.001) and Verbal Learning & Memory (p<.001). Specifically, in the context of high Aβ burden, that is, increased PiB-PET binding or reduced CSF Aβ42, individuals with higher CRF exhibited significantly better cognition compared with individuals with lower CRF. In a late-middle-aged, at-risk cohort, higher CRF is associated with a diminution of Aβ-related effects on cognition. These findings suggest that exercise might play an important role in the prevention of AD. (JINS, 2015, 21, 841-850).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (subject category)
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Schultz, Stephan ...
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Boots, Elizabeth ...
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Almeida, Rodrigo ...
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Oh, Jennifer M
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Einerson, Jean
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Korcarz, Claudia ...
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show more...
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Edwards, Dorothy ...
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Koscik, Rebecca ...
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Dowling, Maritza ...
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Gallagher, Cathe ...
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Bendlin, Barbara ...
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Christian, Bradl ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Carlsson, Cynthi ...
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Asthana, Sanjay
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Hermann, Bruce P
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Sager, Mark A
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Johnson, Sterlin ...
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Stein, James H
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Okonkwo, Ozioma ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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University of Gothenburg