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Cytotoxic Effects of Valproic Acid on Neuroendocrine Tumour Cells.
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- Arvidsson, Yvonne, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Pathology
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- Johanson, Viktor, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
- Pfragner, Roswitha (author)
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- (creator_code:org_t)
- 2015-10-28
- 2016
- English.
- In: Neuroendocrinology. - : S. Karger AG. - 1423-0194 .- 0028-3835. ; 103:5, s. 578-591
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Histone deacetylases (HDACs) modulate lysine acetylation on histones and are frequently deregulated in cancer. HDAC inhibitors with potent anti-tumour effects have been developed and are now being tested in clinical trials. The aim of this study was to investigate the effects of valproic acid (VPA), an inhibitor of class-I and class-IIa HDACs, on neuroendocrine tumour (NET) cell growth.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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- ref (subject category)
- art (subject category)
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