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Extracellular Vesic...
Extracellular Vesicles: Evolving Factors in Stem Cell Biology
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- Nawaz, Muhammad (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Fatima, Farah (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Vallabhaneni, Krishna C. (author)
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Penfornis, Patrice (author)
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- Valadi, Hadi, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Ekström, Karin, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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Kholia, Sharad (author)
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D.Whitt, Jason (author)
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Fernandes, Joseph D. (author)
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Radhika Pochampally, (author)
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Squire, Jeremy A. (author)
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Camussi, Giovanni (author)
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(creator_code:org_t)
- Hindawi Limited, 2016
- 2016
- English.
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In: Stem Cells International. - : Hindawi Limited. - 1687-966X .- 1687-9678. ; 2016:1073140
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Abstract
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- Stem cells are proposed to continuously secrete trophic factors that potentially serve as mediators of autocrine and paracrine activities, associated with reprogramming of the tumor microenvironment, tissue regeneration, and repair. Hitherto, significant efforts have been made to understand the level of underlying paracrine activities influenced by stem cell secreted trophic factors, as little is known about these interactions. Recent findings, however, elucidate this role by reporting the effects of stem cell derived extracellular vesicles (EVs) that mimic the phenotypes of the cells from which they originate. Exchange of genetic information utilizing persistent bidirectional communication mediated by stem cell-EVs could regulate stemness, self-renewal, and differentiation in stem cells and their subpopulations. This review therefore discusses stem cell-EVs as evolving communication factors in stem cell biology, focusing on how they regulate cell fates by inducing persistent and prolonged genetic reprogramming of resident cells in a paracrine fashion. In addition, we address the role of stem cell-secreted vesicles in shaping the tumor microenvironment and immunomodulation and in their ability to stimulate endogenous repair processes during tissue damage. Collectively, these functions ensure an enormous potential for future therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nawaz, Muhammad
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Fatima, Farah
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Vallabhaneni, Kr ...
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Penfornis, Patri ...
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Valadi, Hadi, 19 ...
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Ekström, Karin, ...
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show more...
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Kholia, Sharad
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D.Whitt, Jason
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Fernandes, Josep ...
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Radhika Pochampa ...
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Squire, Jeremy A ...
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Camussi, Giovann ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Stem Cells Inter ...
- By the university
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University of Gothenburg