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Regulation of quies...
Regulation of quiescence and activation of oocyte growth in primordial follicles
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- Adhikari, Deepak (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Liu, Kui (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
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(creator_code:org_t)
- 2012-10-12
- 2013
- English.
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In: Oogenesis. - London : Springer. - 9780857298263 - 9780857298256 ; , s. 49-62
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Abstract
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- Once formed, the pool of dormant primordial follicles serves as the source of developing follicles and fertilizable ova for the duration of a female’s reproductive life. Depending upon the species, primordial follicles can remain quiescent for months, years, or even decades, and the highly regulated process of primordial follicle activation ensures the availability of growing follicles throughout the reproductive period. We have recently begun to elucidate the molecular mechanisms underlying the maintenance of follicular quiescence and the activation of primordial follicles, mainly through the use of genetically modified mouse models. Both overactivation as well as the failure of activation of primordial follicles can lead to pathological conditions such as premature ovarian failure (POF) in the experimental models. A thorough understanding of the underlying mechanisms that regulate quiescence and activation of oocyte growth in primordial follicles will have important biological and clinical implications. © Springer-Verlag London 2013.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Activation
- Primordial follicle
- Quiescence
- Activation
Publication and Content Type
- ref (subject category)
- kap (subject category)
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