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Tasquinimod inhibits prostate cancer growth in bone through alterations in the bone microenvironment.
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- Magnusson, Lisa U., 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Hagberg Thulin, Malin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
- Plas, Pascale (author)
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- Olsson, Anders (author)
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- (creator_code:org_t)
- 2015-12-10
- 2016
- English.
- In: The Prostate. - : Wiley. - 1097-0045 .- 0270-4137. ; 76:4, s. 383-393
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans. Its mechanism of action is not fully elucidated, but previous studies show immunomodulatory and anti-angiogenic effects. The aim of the present study was to investigate the tumor inhibiting effect of tasquinimod in bone of castrated mice as well as to elucidate its working mechanism related to bone microenvironment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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