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Type 2 Diabetes as ...
Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia
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Chatterjee, Saion (author)
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Peters, Sanne (author)
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Woodward, Mark (author)
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Arango, Silvia (author)
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Batty, David (author)
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Beckett, Nigel (author)
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Beiser, Alexa (author)
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Borenstein, Amy (author)
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Crane, Paul (author)
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Haan, Mary (author)
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- Hassing, Linda, 1967 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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Hayden, Kathleen (author)
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Yutaka, Kiyohara (author)
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Larson, Eric (author)
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Li, Chung-Yi (author)
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Ninomiya, Toshiharu (author)
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Ohara, Tomoyuki (author)
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Peters, Ruth (author)
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Russ, Tom (author)
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Seshadri, Sudha (author)
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Strand, Bjorn (author)
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Walker, Rod (author)
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- Xu, Weili (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China
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Huxley, Rachel (author)
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(creator_code:org_t)
- 2015-12-17
- 2016
- English.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 39:2, s. 300-307
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https://care.diabete...
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https://gup.ub.gu.se...
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Abstract
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- OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. RESEARCH DESIGN AND METHODS A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. RESULTS Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45–1.80]; men: pooled RR 1.58 [95% CI 1.38–1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86–2.94) in women and 1.73 (95% CI 1.61–1.85) in men, and for nonvascular dementia the RRs were 1.53 (95% CI 1.35–1.73) in women and 1.49 (95% CI 1.31–1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08–1.30]; P < 0.001). CONCLUSIONS Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Dementia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chatterjee, Saio ...
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Peters, Sanne
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Woodward, Mark
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Arango, Silvia
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Batty, David
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Beckett, Nigel
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show more...
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Beiser, Alexa
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Borenstein, Amy
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Crane, Paul
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Haan, Mary
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Hassing, Linda, ...
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Hayden, Kathleen
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Yutaka, Kiyohara
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Larson, Eric
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Li, Chung-Yi
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Ninomiya, Toshih ...
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Ohara, Tomoyuki
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Peters, Ruth
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Russ, Tom
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Seshadri, Sudha
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Strand, Bjorn
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Walker, Rod
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Xu, Weili
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Huxley, Rachel
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Diabetes Care
- By the university
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University of Gothenburg
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Stockholm University
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Karolinska Institutet