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Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia
- Chatterjee, Saion (author)
- Peters, Sanne (author)
- Woodward, Mark (author)
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- Arango, Silvia (author)
- Batty, David (author)
- Beckett, Nigel (author)
- Beiser, Alexa (author)
- Borenstein, Amy (author)
- Crane, Paul (author)
- Haan, Mary (author)
- Hayden, Kathleen (author)
- Yutaka, Kiyohara (author)
- Larson, Eric (author)
- Li, Chung-Yi (author)
- Ninomiya, Toshiharu (author)
- Ohara, Tomoyuki (author)
- Peters, Ruth (author)
- Russ, Tom (author)
- Seshadri, Sudha (author)
- Strand, Bjorn (author)
- Walker, Rod (author)
- Huxley, Rachel (author)
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- (creator_code:org_t)
- 2015-12-17
- 2016
- English.
- In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 39:2, s. 300-307
- Journal article (peer-reviewed)
Abstract
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- OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. RESEARCH DESIGN AND METHODS A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. RESULTS Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45–1.80]; men: pooled RR 1.58 [95% CI 1.38–1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86–2.94) in women and 1.73 (95% CI 1.61–1.85) in men, and for nonvascular dementia the RRs were 1.53 (95% CI 1.35–1.73) in women and 1.49 (95% CI 1.31–1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08–1.30]; P < 0.001). CONCLUSIONS Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Dementia
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- art (subject category)
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- Peters, Sanne
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- Beiser, Alexa
- Borenstein, Amy
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- Hayden, Kathleen
- Yutaka, Kiyohara
- Larson, Eric
- Li, Chung-Yi
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- Ohara, Tomoyuki
- Peters, Ruth
- Russ, Tom
- Seshadri, Sudha
- Strand, Bjorn
- Walker, Rod
- Xu, Weili
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