Search: onr:"swepub:oai:gup.ub.gu.se/228909" > Genome-wide associa...
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000 | 07887naa a2201633 4500 | |
001 | oai:gup.ub.gu.se/228909 | |
003 | SwePub | |
008 | 240528s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2289092 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddv4722 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Felix, Janine F4 aut |
245 | 1 0 | a Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. |
264 | c 2015-11-24 | |
264 | 1 | b Oxford University Press (OUP),c 2016 |
520 | a A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
700 | 1 | a Bradfield, Jonathan P4 aut |
700 | 1 | a Monnereau, Claire4 aut |
700 | 1 | a van der Valk, Ralf J P4 aut |
700 | 1 | a Stergiakouli, Evie4 aut |
700 | 1 | a Chesi, Alessandra4 aut |
700 | 1 | a Gaillard, Romy4 aut |
700 | 1 | a Feenstra, Bjarke4 aut |
700 | 1 | a Thiering, Elisabeth4 aut |
700 | 1 | a Kreiner-Møller, Eskil4 aut |
700 | 1 | a Mahajan, Anubha4 aut |
700 | 1 | a Pitkänen, Niina4 aut |
700 | 1 | a Joro, Raimo4 aut |
700 | 1 | a Cavadino, Alana4 aut |
700 | 1 | a Huikari, Ville4 aut |
700 | 1 | a Franks, Steve4 aut |
700 | 1 | a Groen-Blokhuis, Maria M4 aut |
700 | 1 | a Cousminer, Diana L4 aut |
700 | 1 | a Marsh, Julie A4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Curtin, John A4 aut |
700 | 1 | a Vioque, Jesus4 aut |
700 | 1 | a Ahluwalia, Tarunveer S4 aut |
700 | 1 | a Myhre, Ronny4 aut |
700 | 1 | a Price, Thomas S4 aut |
700 | 1 | a Vilor-Tejedor, Natalia4 aut |
700 | 1 | a Yengo, Loïc4 aut |
700 | 1 | a Grarup, Niels4 aut |
700 | 1 | a Ntalla, Ioanna4 aut |
700 | 1 | a Ang, Wei4 aut |
700 | 1 | a Atalay, Mustafa4 aut |
700 | 1 | a Bisgaard, Hans4 aut |
700 | 1 | a Blakemore, Alexandra I4 aut |
700 | 1 | a Bonnefond, Amelie4 aut |
700 | 1 | a Carstensen, Lisbeth4 aut |
700 | 1 | a Eriksson, Johan4 aut |
700 | 1 | a Flexeder, Claudia4 aut |
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700 | 1 | a Geller, Frank4 aut |
700 | 1 | a Geserick, Mandy4 aut |
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700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Holm, Jens-Christian4 aut |
700 | 1 | a Horikoshi, Momoko4 aut |
700 | 1 | a Hottenga, Jouke Jan4 aut |
700 | 1 | a Huang, Jinyan4 aut |
700 | 1 | a Kadarmideen, Haja N4 aut |
700 | 1 | a Kähönen, Mika4 aut |
700 | 1 | a Kiess, Wieland4 aut |
700 | 1 | a Lakka, Hanna-Maaria4 aut |
700 | 1 | a Lakka, Timo A4 aut |
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700 | 1 | a Lyytikäinen, Leo-Pekka4 aut |
700 | 1 | a Ma, Baoshan4 aut |
700 | 1 | a Magnus, Per4 aut |
700 | 1 | a McCormack, Shana E4 aut |
700 | 1 | a McMahon, George4 aut |
700 | 1 | a Mentch, Frank D4 aut |
700 | 1 | a Middeldorp, Christel M4 aut |
700 | 1 | a Murray, Clare S4 aut |
700 | 1 | a Pahkala, Katja4 aut |
700 | 1 | a Pers, Tune H4 aut |
700 | 1 | a Pfäffle, Roland4 aut |
700 | 1 | a Postma, Dirkje S4 aut |
700 | 1 | a Power, Christine4 aut |
700 | 1 | a Simpson, Angela4 aut |
700 | 1 | a Sengpiel, Verena,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsenve |
700 | 1 | a Tiesler, Carla M T4 aut |
700 | 1 | a Torrent, Maties4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a van Meurs, Joyce B4 aut |
700 | 1 | a Vinding, Rebecca4 aut |
700 | 1 | a Waage, Johannes4 aut |
700 | 1 | a Wardle, Jane4 aut |
700 | 1 | a Zeggini, Eleftheria4 aut |
700 | 1 | a Zemel, Babette S4 aut |
700 | 1 | a Dedoussis, George V4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Sunyer, Jordi4 aut |
700 | 1 | a Plomin, Robert4 aut |
700 | 1 | a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Gonzalez, Juan R4 aut |
700 | 1 | a Custovic, Adnan4 aut |
700 | 1 | a Raitakari, Olli T4 aut |
700 | 1 | a Pennell, Craig E4 aut |
700 | 1 | a Widén, Elisabeth4 aut |
700 | 1 | a Boomsma, Dorret I4 aut |
700 | 1 | a Koppelman, Gerard H4 aut |
700 | 1 | a Sebert, Sylvain4 aut |
700 | 1 | a Järvelin, Marjo-Riitta4 aut |
700 | 1 | a Hyppönen, Elina4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Lindi, Virpi4 aut |
700 | 1 | a Harri, Niinikoski4 aut |
700 | 1 | a Körner, Antje4 aut |
700 | 1 | a Bønnelykke, Klaus4 aut |
700 | 1 | a Heinrich, Joachim4 aut |
700 | 1 | a Melbye, Mads4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Ring, Susan M4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a Sørensen, Thorkild I A4 aut |
700 | 1 | a Timpson, Nicholas J4 aut |
700 | 1 | a Grant, Struan F A4 aut |
700 | 1 | a Jaddoe, Vincent W V4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
773 | 0 | t Human molecular geneticsd : Oxford University Press (OUP)g 25:2, s. 389-403q 25:2<389-403x 1460-2083x 0964-6906 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/25/2/389/18526832/ddv472.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/228909 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddv472 |
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