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Using florbetapir p...
Using florbetapir positron emission tomography to explore cerebrospinal fluid cut points and gray zones in small sample sizes
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Weston, P. S. J. (author)
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Paterson, R. W. (author)
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Modat, M. (author)
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Burgos, N. (author)
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Cardoso, M. J. (author)
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Magdalinou, N. (author)
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Lehmann, M. (author)
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Dickson, J. C. (author)
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Barnes, A. (author)
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Bomanji, J. B. (author)
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Kayani, I. (author)
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Cash, D. M. (author)
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Ourselin, S. (author)
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Toombs, J. (author)
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Lunn, M. P. (author)
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Mummery, C. J. (author)
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Warren, J. D. (author)
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Rossor, M. N. (author)
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Fox, N. C. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, J. M. (author)
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(creator_code:org_t)
- 2015-11-02
- 2015
- English.
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In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - : Wiley. - 2352-8729. ; 1:4, s. 440-446
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https://doi.org/10.1...
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Abstract
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- Introduction: We aimed to assess the feasibility of determining Alzheimer's disease cerebrospinal fluid (CSF) cut points in small samples through comparison with amyloid positron emission tomography (PET). Methods: Twenty-three individuals (19 patients, four controls) had CSF measures of amyloid beta (Aβ)1-42 and total tau/Aβ1-42 ratio, and florbetapir PET. We compared CSF measures with visual and quantitative (standardized uptake value ratio [SUVR]) PET measures of amyloid. Results: Seventeen of 23 were amyloid-positive on visual reads, and 14 of 23 at an SUVR of ≥1.1. There was concordance (positive/negative on both measures) in 20 of 23, of whom 19 of 20 were correctly classified at an Aβ1-42 of 630 ng/L, and 20 of 20 on tau/Aβ1-42 ratio (positive ≥0.88; negative ≤0.34). Three discordant cases had Aβ1-42 levels between 403 and 729 ng/L and tau/Aβ1-42 ratios of 0.54-0.58. Discussion: Comparing amyloid PET and CSF biomarkers provides a means of assessing CSF cut points in vivo, and can be applied to small sample sizes. CSF tau/Aβ1-42 ratio appears robust at predicting amyloid status, although there are gray zones where there remains diagnostic uncertainty. © 2015 The Authors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Amyloid PET
- Aβ
- Cerebrospinal fluid
- Cut points
- Diagnosis
- Phosphorylated tau
- Tau
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Weston, P. S. J.
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Paterson, R. W.
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Modat, M.
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Burgos, N.
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Cardoso, M. J.
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Magdalinou, N.
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show more...
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Lehmann, M.
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Dickson, J. C.
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Barnes, A.
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Bomanji, J. B.
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Kayani, I.
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Cash, D. M.
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Ourselin, S.
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Toombs, J.
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Lunn, M. P.
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Mummery, C. J.
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Warren, J. D.
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Rossor, M. N.
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Fox, N. C.
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Zetterberg, Henr ...
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Schott, J. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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University of Gothenburg