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Consensus statement...
Consensus statement for diagnosis of subcortical small vessel disease
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Rosenberg, G. A. (author)
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- Wallin, Anders, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Wardlaw, J. M. (author)
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Markus, H. S. (author)
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Montaner, J. (author)
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Wolfson, L. (author)
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Iadecola, C. (author)
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Zlokovic, B. V. (author)
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Joutel, A. (author)
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Dichgans, M. (author)
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Duering, M. (author)
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Schmidt, R. (author)
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Korczyn, A. D. (author)
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Grinberg, L. T. (author)
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Chui, H. C. (author)
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Hachinski, V. (author)
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(creator_code:org_t)
- 2015-07-22
- 2016
- English.
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In: Journal of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 0271-678X .- 1559-7016. ; 36:1, s. 6-25
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Vascular cognitive impairment (VCI) is the diagnostic term used to describe a heterogeneous group of sporadic and hereditary diseases of the large and small blood vessels. Subcortical small vessel disease (SVD) leads to lacunar infarcts and progressive damage to the white matter. Patients with progressive damage to the white matter, referred to as Binswanger's disease (BD), constitute a spectrum from pure vascular disease to a mixture with neurodegenerative changes. Binswanger's disease patients are a relatively homogeneous subgroup with hypoxic hypoperfusion, lacunar infarcts, and inflammation that act synergistically to disrupt the blood-brain barrier (BBB) and break down myelin. Identification of this subgroup can be facilitated by multimodal disease markers obtained from clinical, cerebrospinal fluid, neuropsychological, and imaging studies. This consensus statement identifies a potential set of biomarkers based on underlying pathologic changes that could facilitate diagnosis and aid patient selection for future collaborative treatment trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Binswanger's disease
- blood-brain barrier permeability
- cerebrospinal fluid
- inflammation
- blood-brain-barrier
- vascular cognitive impairment
- white-matter
- lesions
- chronic cerebral hypoperfusion
- stroke-prone rats
- autosomal-dominant arteriopathy
- dilated perivascular spaces
- carotid-artery occlusion
- gd-dtpa mri
- alzheimers-disease
- Endocrinology & Metabolism
- Hematology
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rosenberg, G. A.
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Wallin, Anders, ...
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Wardlaw, J. M.
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Markus, H. S.
-
Montaner, J.
-
Wolfson, L.
-
show more...
-
Iadecola, C.
-
Zlokovic, B. V.
-
Joutel, A.
-
Dichgans, M.
-
Duering, M.
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Schmidt, R.
-
Korczyn, A. D.
-
Grinberg, L. T.
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Chui, H. C.
-
Hachinski, V.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Cereb ...
- By the university
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University of Gothenburg