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- Elliott, J. A. (author)
Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- Ovid Technologies (Wolters Kluwer Health),2015
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- LIBRIS-ID:oai:gup.ub.gu.se/231828
- https://gup.ub.gu.se/publication/231828URI
- https://doi.org/10.1097/sla.0000000000001465DOI
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- Language:English
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- Objectives:To characterize the gut hormone profile and determine the effect of satiety gut hormone blockade on food intake in disease-free postesophagectomy patients.Background:Improved oncologic outcomes for esophageal cancer have resulted in increased survivorship and a focus on health-related quality of life. Anorexia and early satiety are common, but putative causative factors, in particular the gut-brain hormonal axis, have not been systematically studied.Methods:In a double-blind, placebo-controlled, randomized crossover study, disease-free patients at least 1 year postresection and gastric conduit reconstruction received either 1mL 0.9% saline or 1mL (100g) octreotide acetate subcutaneously followed by a standardized ad libitum meal on each of two assessments. Fasting and postprandial plasma glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and ghrelin immunoreactivity were measured. Gut hormone responses and calorie intake postsaline versus octreotide were compared between experimental and control groups.Results:Eighteen subjects [esophagectomy (ES), n=10, 2.40.75 years postresection; and unoperated control subjects, n=8] were studied. ES demonstrated significant weight loss at 3, 6, 12, and 24 months postoperatively (all P<0.05). Ghrelin levels were similar (P=0.58) for both groups, but postprandial GLP-1 and PYY responses were significantly (P<0.001) greater among ES as compared with controls. After octreotide, ad libitum calorie intake increased among ES (1.5 +/- 0.2 fold-change, P=0.02) but not controls (1.1 +/- 0.1 fold-change, P=0.30).Conclusions:ES demonstrated an exaggerated postprandial satiety gut hormone response that was attenuated by octreotide, thus identifying a potential therapeutic target to modulate in the ES patient with early satiety.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- esophageal carcinoma
- esophagectomy
- esophagogastric junction
- gastric conduit
- ghrelin
- glucagon-
- quality-of-life
- somatostatin receptor subtype-5
- rat intestinal
- cultures
- glucagon-like peptide-1
- serum ghrelin levels
- body-weight
- loss
- cancer-surgery
- tube reconstruction
- sleeve gastrectomy
- enteral
- nutrition
- Surgery
Added entries (persons, corporate bodies, meetings, titles ...)
- Jackson, S. (author)
- King, S. (author)
- McHugh, R. (author)
- Docherty, N. G. (author)
- Reynolds, J. V. (author)
- le Roux, Carel WGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xleroc (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning (creator_code:org_t)
Related titles
- In:Annals of Surgery: Ovid Technologies (Wolters Kluwer Health)262:5, s. 824-8300003-4932
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