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A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia.
- Hughes, Timothy (author)
- Hansson, Lars (author)
- Sønderby, Ida E (author)
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- Athanasiu, Lavinia (author)
- Zuber, Verena (author)
- Tesli, Martin (author)
- Melle, Ingrid (author)
- Andreassen, Ole Andreas (author)
- Djurovic, Srdjan (author)
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- (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
- In: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 80:4, s. 323-330
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Ankyrin-3 (ANK3) was one of the first genes to reach significance in a bipolar disorder genome-wide association study. Many subsequent association studies confirmed this finding and implicated this gene in schizophrenia. However, the exact nature of the role of ANK3 in the pathophysiology remains elusive. In particular, the specific isoforms involved and the nature of the imbalance are unknown.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- ANK3; Bipolar disorder; Genetics; Minor isoform; Schizophrenia; Splice site
Publication and Content Type
- ref (subject category)
- art (subject category)
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