A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia.

Ankyrin-3 (ANK3) was one of the first genes to reach significance in a bipolar disorder genome-wide association study. Many subsequent association studies confirmed this finding and implicated this gene in schizophrenia. However, the exact nature of the role of ANK3 in the pathophysiology remains elusive. In particular, the specific isoforms involved and the nature of the imbalance are unknown.

Hansson, Lars (author)
Sønderby, Ida E (author)
Athanasiu, Lavinia (author)
Zuber, Verena (author)
Tesli, Martin (author)
Song, JieKarolinska Institutet (author)
Hultman, Christina MKarolinska Institutet (author)
Bergen, Sarah EKarolinska Institutet (author)
Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
Melle, Ingrid (author)
Andreassen, Ole Andreas (author)
Djurovic, Srdjan (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

By the author/editor: Hughes, Timothy; Hansson, Lars; Sønderby, Ida E; Athanasiu, Lavin ...; Zuber, Verena; Tesli, Martin; show more...; Song, Jie; Hultman, Christi ...; Bergen, Sarah E; Landén, Mikael, ...; Melle, Ingrid; Andreassen, Ole ...; Djurovic, Srdjan; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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