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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04184naa a2200553 4500 | |
| 001 | oai:gup.ub.gu.se/232404 | |
| 003 | SwePub | |
| 008 | 240528s2015 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-356004 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2324042 URI |
| 024 | 7 | a https://doi.org/10.1021/acs.jnatprod.5b005812 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3560042 URI |
| 040 | a (SwePub)gud (SwePub)uu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Deyou, Tsegayeu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut |
| 245 | 1 0 | a Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis |
| 264 | c 2015-12-14 | |
| 264 | 1 | b American Chemical Society (ACS),c 2015 |
| 520 | a Five new compounds, 4-O-geranylisoliquiritigenin (1), 12-dihydrousararotenoid B (2), 12-dihydrousararotenoid C (3), 4'-O-geranyl-7-hydroxyflavanone (4), and 4'O-geranyl-7-hydroxydihydroflavanol (5), along with 12 known natural products (6-17) were isolated from the CH2Cl2/MeOH (1:1) extract of the root bark of Millettia usaramensis ssp. usaramensis by chromatographic separation. The purified metabolites were identified by NMR spectroscopic and mass spectrometric analyses, whereas their absolute configurations were established on the basis of chiroptical data and in some cases also by X-ray crystallography. The crude extract was moderately active (IC50 = 11.63 mu g/mL) against the ER-negative MDB-MB-231 human breast cancer cell line, and accordingly compounds 6, 8, 9, 10, 12, and 16 also showed moderate to low cytotoxic activities (IC50 25.7-207.2 mu M). The new natural product 1 exhibited antiplasmodial activity with IC50 values of 3.7 and 5.3 mu M against the chloroquine-sensitive 3D7 and the chloroquine-resistant Dd2 Plasmodium falciparum strains, respectively, and was also cytotoxic to the HEK293 cell line. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Andra medicinska och farmaceutiska grundvetenskaper0 (SwePub)301992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Other Basic Medicine0 (SwePub)301992 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng |
| 653 | a SUBSPECIES USARAMENSIS | |
| 653 | a CONSTITUENTS | |
| 653 | a FERRUGINEA | |
| 653 | a DURA | |
| 700 | 1 | a Gumula, Ivanu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut |
| 700 | 1 | a Pang, F. F.4 aut |
| 700 | 1 | a Gruhonjic, Amrau Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Sahlgrenska Cancer Center,Department of Chemistry and Molecular Biology4 aut |
| 700 | 1 | a Mumo, M.4 aut |
| 700 | 1 | a Holleran, J.4 aut |
| 700 | 1 | a Duffy, S.4 aut |
| 700 | 1 | a Fitzpatrick, Paul A.u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xfitpa |
| 700 | 1 | a Heydenreich, M.4 aut |
| 700 | 1 | a Landberg, Göran,d 1963u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xlgora |
| 700 | 1 | a Derese, S.4 aut |
| 700 | 1 | a Avery, V.4 aut |
| 700 | 1 | a Rissanen, K.4 aut |
| 700 | 1 | a Erdelyi, Mate,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,organisk kemi4 aut0 (Swepub:uu)mateerde |
| 700 | 1 | a Yenesew, A.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
| 773 | 0 | t Journal of Natural Productsd : American Chemical Society (ACS)g 78:12, s. 2932-2939q 78:12<2932-2939x 0163-3864x 1520-6025x 0974-5211 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/232404 |
| 856 | 4 8 | u https://doi.org/10.1021/acs.jnatprod.5b00581 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356004 |
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