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An innate antiviral...
An innate antiviral pathway acting before interferons at epithelial surfaces
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Iversen, M. B. (author)
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Reinert, L. S. (author)
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Thomsen, M. K. (author)
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Bagdonaite, I. (author)
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Nandakumar, R. (author)
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Cheshenko, N. (author)
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Prabakaran, T. (author)
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Vakhrushev, S. Y. (author)
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Krzyzowska, M. (author)
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Kratholm, S. K. (author)
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Ruiz-Perez, F. (author)
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Petersen, S. V. (author)
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Goriely, S. (author)
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Bibby, B. M. (author)
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- Eriksson, Kristina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Rulandl, J. (author)
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Thomsen, A. R. (author)
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Herold, B. C. (author)
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Wandall, H. H. (author)
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Frischel, S. (author)
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Hom, C. K. (author)
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Paludan, S. R. (author)
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(creator_code:org_t)
- 2015-11-30
- 2016
- English.
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In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 17:2, s. 150-158
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Abstract
Subject headings
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- Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a manner dependent on neutrophils. This study therefore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial surfaces before the classical IFN response is operative.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- herpes-simplex-virus
- dendritic cells
- kappa-b
- recognition
- infection
- immunity
- transcription
- activation
- protection
- challenge
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Iversen, M. B.
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Reinert, L. S.
-
Thomsen, M. K.
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Bagdonaite, I.
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Nandakumar, R.
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Cheshenko, N.
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show more...
-
Prabakaran, T.
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Vakhrushev, S. Y ...
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Krzyzowska, M.
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Kratholm, S. K.
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Ruiz-Perez, F.
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Petersen, S. V.
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Goriely, S.
-
Bibby, B. M.
-
Eriksson, Kristi ...
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Rulandl, J.
-
Thomsen, A. R.
-
Herold, B. C.
-
Wandall, H. H.
-
Frischel, S.
-
Hom, C. K.
-
Paludan, S. R.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Nature Immunolog ...
- By the university
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University of Gothenburg