onr:"swepub:oai:gup.ub.gu.se/233195"
Search: onr:"swepub:oai:gup.ub.gu.se/233195" > Impact of a cis-ass...
- 1 of 1
- Previous record
- Next record
- To hitlist
Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance
- Li, M. (author)
- Luo, X. J. (author)
-
- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
- show more...
- Li, X. (author)
- Zhang, W. (author)
- Yao, Y. G. (author)
- Zhang, C. (author)
- Liu, J. W. (author)
- Mattheisen, M. (author)
- Cichon, S. (author)
- Muehleisen, T. W. (author)
- Degenhardt, F. A. (author)
- Noethen, M. M. (author)
- Schulze, T. G. (author)
- Grigoroiu-Serbanescu, M. (author)
- Li, H. (author)
- Fuller, C. K. (author)
- Chen, C. H. (author)
- Dong, Q. (author)
- Chen, C. S. (author)
- Jamain, S. (author)
- Leboyer, M. (author)
- Bellivier, F. (author)
- Etain, B. (author)
- Kahn, J. P. (author)
- Henry, C. (author)
- Preisig, M. (author)
- Kutalik, Z. (author)
- Castelao, E. (author)
- Wright, A. (author)
- Mitchell, P. B. (author)
- Fullerton, J. M. (author)
- Schofield, P. R. (author)
- Montgomery, G. W. (author)
- Medland, S. E. (author)
- Gordon, S. D. (author)
- Martin, N. G. (author)
- Rietschel, M. (author)
- Liu, C. Y. (author)
- Kleinman, J. E. (author)
- Hyde, T. M. (author)
- Weinberger, D. R. (author)
- Su, B. (author)
- show less...
- (creator_code:org_t)
- 2018-01-02
- 2016
- English.
- In: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 208:2, s. 128-137
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain. We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder genome-wide association studies (GWAS) and brain eQTL. To detect single nucleotide polymorphisms (SNPs) that influence expression levels of genes associated with bipolar disorder, we jointly analysed data from a bipolar disorder GWAS (7481 cases and 9250 controls) and a genome-wide brain (cortical) eQTL (193 healthy controls) using a Bayesian statistical method, with independent follow-up replications. The identified risk SNP was then further tested for association with hippocampal volume (n = 577 5) and cognitive performance (n = 342) among healthy individuals. Integrative analysis revealed a significant association between a brain eQTL rs6088662 on chromosome 20q11.22 and bipolar disorder (log Bayes factor = 5.48; bipolar disorder P=5.85 x 10(-5)). Follow-up studies across multiple independent samples confirmed the association of the risk SNP (rs6088662) with gene expression and bipolar disorder susceptibility (P=3.54 x 10(-8)). Further exploratory analysis revealed that rs6088662 is also associated with hippocampal volume and cognitive performance in healthy individuals. Our findings suggest that 20q11.22 is likely a risk region for bipolar disorder; they also highlight the informative value of integrating functional annotation of genetic variants for gene expression in advancing our understanding of the biological basis underlying complex disorders, such as bipolar disorder.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- genome-wide association
- human prefrontal cortex
- human brain
- common
- variants
- schizophrenia
- risk
- disease
- metaanalysis
- replication
- cacna1c
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- British Journal of Psychiatry (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Li, M.
- Luo, X. J.
- Landén, Mikael, ...
- Bergen, S. E.
- Hultman, C. M.
- Li, X.
- show more...
- Zhang, W.
- Yao, Y. G.
- Zhang, C.
- Liu, J. W.
- Mattheisen, M.
- Cichon, S.
- Muehleisen, T. W ...
- Degenhardt, F. A ...
- Noethen, M. M.
- Schulze, T. G.
- Grigoroiu-Serban ...
- Li, H.
- Fuller, C. K.
- Chen, C. H.
- Dong, Q.
- Chen, C. S.
- Jamain, S.
- Leboyer, M.
- Bellivier, F.
- Etain, B.
- Kahn, J. P.
- Henry, C.
- Preisig, M.
- Kutalik, Z.
- Castelao, E.
- Wright, A.
- Mitchell, P. B.
- Fullerton, J. M.
- Schofield, P. R.
- Montgomery, G. W ...
- Medland, S. E.
- Gordon, S. D.
- Martin, N. G.
- Rietschel, M.
- Liu, C. Y.
- Kleinman, J. E.
- Hyde, T. M.
- Weinberger, D. R ...
- Su, B.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Psychiatry
- Articles in the publication
- British Journal ...
- By the university
- University of Gothenburg
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
