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The single breath n...
The single breath nitrogen test and mortality - A 38 years follow up
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- Olofson, Jan, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden.
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- Bake, Björn, 1939 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden.
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- Bergman, Bengt, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden.
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- Svärdsudd, Kurt (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 112, s. 75-80
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Abstract
Subject headings
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- Background: Spirometry data predict mortality, but are less sensitive to detect dysfunction in small airways as compared to the slope of phase III (the N-2 slope) of the single breath nitrogen test. The association between the N-2 slope and mortality has been studied with conflicting results. In the present study the prognostic importance of the N-2 slope was tested taking spirometry variables into account. Methods: A systematic general population sample of 595 middle-aged men had a baseline investigation with lung function tests including spirometry and the N-2 slope. Age, smoking, and anthropometry variables were registered. The cohort was followed up regarding survival for 38 years. Results: The sample was subdivided by tertiles of the N-2 slope. A proportional hazards regression analysis was performed for each group of covariates: anthropometric, smoking variables, and spirometry variables, after accounting for age. Covariates with significant impact on mortality and the highest chi-square levels were smoking habit score and forced expired volume in 1 s corrected for height. These variables, in addition to age and the N-2 tertiles were entered into a final proportional hazards regression analysis. In this multivariate model, mortality was significantly related to age (p < .0001), smoking habit score (p < .0001) and the N-2 tertiles (p = .0004), but not to FEV1 when N-2 slope was allowed for in the model. Conclusions: Dysfunction in small airways as measured by the N-2 slope is significantly associated with overall mortality in middle-aged men, and outrivals spirometry as a predictor in multivariate analysis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Mortality
- Single breath nitrogen test
- Spirometry
- Smoking
- Small airways function
- Epidemiology
- lung-function
- pulmonary-function
- small airways
- respiratory symptoms
- alveolar plateau
- closing volume
- population
- disease
- smoking
- asthma
- Cardiovascular System & Cardiology
- Respiratory System
- Mortality
Publication and Content Type
- ref (subject category)
- art (subject category)
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