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Mitral regurgitatio...
Mitral regurgitation quantification by cardiovascular magnetic resonance: a comparison of indirect quantification methods
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- Polte, Christian Lars (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Bech-Hanssen, Odd, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Johnsson, Åse (Allansdotter), 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Gao, Sinsia, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Lagerstrand, Kerstin M (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics
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(creator_code:org_t)
- 2015-05-23
- 2015
- English.
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In: The International Journal of Cardiovascular Imaging. - : Springer Science and Business Media LLC. - 1569-5794 .- 1573-0743. ; 31:6, s. 1223-31
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Abstract
Subject headings
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- Quantification of mitral regurgitation (MR) using cardiovascular magnetic resonance can be achieved by three indirect methods. The aims of the study were to determine their agreement, observer variability and effect on grading MR severity. The study comprised 16 healthy volunteers and 36 MR patients. Quantification was performed using the 'standard' [left ventricular stroke volume (LVSV)-aortic forward flow (AoFF)], 'volumetric' [LVSV-right ventricular stroke volume (RVSV)] and 'flow' method [mitral inflow (MiIF)-AoFF]. In healthy volunteers without MR, LVSV was larger than AoFF (mean difference ±SD: 12 ± 6 ml, P < 0.0001). Only small differences were found between LVSV-RVSV (3 ± 6 ml) and MiIF-AoFF (1 ± 5 ml). In patients, mitral regurgitant volumes (MRVs)/fractions (MRFs) were larger (P < 0.0001) using the 'standard' method (90 ± 31 ml/51 ± 11%) compared with the 'volumetric' (76 ± 30 ml/42 ± 11%) and 'flow' method (70 ± 32 ml/44 ± 15%). Inter-observer variability was lowest for the 'flow' and highest for the 'volumetric' method, while intra-observer variability was similar for all three methods. In 29 operated patients with severe MR, MRVs were above the guideline threshold (≥60 ml) in 100, 86 and 83% of the cases, and MRFs were above the threshold (≥50%) in 76, 32 and 48% of the cases, when using the 'standard', 'volumetric' and 'flow' method respectively. In conclusion, the choice of method can affect the grading of MR severity and thereby eventually the clinical decision-making and timing of surgery.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Cardiovascular magnetic resonance; mitral regurgitation
Publication and Content Type
- ref (subject category)
- art (subject category)
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