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Role of natural kil...
Role of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid leukemia
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- Martner, Anna, 1979 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Rydström, Anna, 1976 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Riise, Rebecca E, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Infectious Medicine
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- Aurelius, Johan, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Sahlgrenska Cancer Center,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Anderson, H. (author)
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- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Foa, R. (author)
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- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Bergh Thorén, Fredrik, 1976 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- 2015-05-05
- 2016
- English.
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In: Oncoimmunology. - : Informa UK Limited. - 2162-402X. ; 5:1
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Abstract
Subject headings
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- In a phase IV trial, 84 patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose human recombinant interleukin 2 (IL-2) for 18 months to prevent leukemic relapse. During cycles, the treatment resulted in expansion of CD56(bright) (CD3 /16 /56(bright)) and CD16(+) (CD3 /16(+)/56(+)) natural killer (NK) cells in the blood along with increased NK cell expression of the natural cytotoxicity receptors (NCRs) NKp30 and NKp46. Multivariate analyses correcting for age and risk group demonstrated that high CD56(bright) NK cell counts and high expression of NKp30 or NKp46 on CD16(+) NK cells independently predicted leukemia-free survival (LFS) and overall survival (OS). Our results suggest that the dynamics of NK cell subsets and their NCR expression may determine the efficiency of relapse-preventive immunotherapy in AML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- acute myeloid leukemia
- immunotherapy
- natural cytotoxicity receptors
- natural killer cells
- 1st complete remission
- acute myelogenous leukemia
- nk cells
- histamine
- dihydrochloride
- recombinant interleukin-2
- cytokine production
- phase-3
- trial
- transplantation
- maintenance
- induction
- Oncology
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Martner, Anna, 1 ...
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Rydström, Anna, ...
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Riise, Rebecca E ...
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Aurelius, Johan, ...
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Anderson, H.
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Brune, Mats, 195 ...
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show more...
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Foa, R.
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Hellstrand, Kris ...
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Bergh Thorén, Fr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Oncoimmunology
- By the university
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University of Gothenburg