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  • Martner, Anna,1979Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine (author)

Role of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid leukemia

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2015-05-05
  • Informa UK Limited,2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/235925
  • https://gup.ub.gu.se/publication/235925URI
  • https://doi.org/10.1080/2162402x.2015.1041701DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In a phase IV trial, 84 patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose human recombinant interleukin 2 (IL-2) for 18 months to prevent leukemic relapse. During cycles, the treatment resulted in expansion of CD56(bright) (CD3 /16 /56(bright)) and CD16(+) (CD3 /16(+)/56(+)) natural killer (NK) cells in the blood along with increased NK cell expression of the natural cytotoxicity receptors (NCRs) NKp30 and NKp46. Multivariate analyses correcting for age and risk group demonstrated that high CD56(bright) NK cell counts and high expression of NKp30 or NKp46 on CD16(+) NK cells independently predicted leukemia-free survival (LFS) and overall survival (OS). Our results suggest that the dynamics of NK cell subsets and their NCR expression may determine the efficiency of relapse-preventive immunotherapy in AML.

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  • Rydström, Anna,1976Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xrydsa (author)
  • Riise, Rebecca E,1987Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xriire (author)
  • Aurelius, Johan,1980Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Sahlgrenska Cancer Center,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xaurjo (author)
  • Anderson, H. (author)
  • Brune, Mats,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xbrunm (author)
  • Foa, R. (author)
  • Hellstrand, Kristoffer,1956Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xhellk (author)
  • Bergh Thorén, Fredrik,1976Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xthofr (author)
  • Göteborgs universitetSahlgrenska Cancer Center (creator_code:org_t)

Related titles

  • In:Oncoimmunology: Informa UK Limited5:12162-402X

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