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Adjuvant ovarian fu...
Adjuvant ovarian function suppression and cognitive function in women with breast cancer
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-04-19
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Springer Science and Business Media LLC,2016
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LIBRIS-ID:oai:gup.ub.gu.se/237113
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https://gup.ub.gu.se/publication/237113URI
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https://doi.org/10.1038/bjc.2016.71DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: To examine the effect on cognitive function of adjuvant ovarian function suppression (OFS) for breast cancer. Methods: The Suppression of Ovarian Function (SOFT) trial randomised premenopausal women with hormone receptor-positive breast cancer to 5 years adjuvant endocrine therapy with tamoxifen + OFS, exemestane + OFS or tamoxifen alone. The Co-SOFT substudy assessed objective cognitive function and patient reported outcomes at randomisation (T0), and 1 year later (T1); the primary endpoint was change in global cognitive function, measured by the composite objective cognitive function score. Data were compared for the pooled tamoxifen + OFS and exemestane + OFS groups vs the tamoxifen alone group using the Wilcoxon rank-sum test. Results: Of 86 participants, 74 underwent both T0 and T1 cognitive testing; 54 randomised to OFS+ either tamoxifen (28) or exemestane (26) and 20 randomised to tamoxifen alone. There was no significant difference in the changes in the composite cognitive function scores between the OFS+ tamoxifen or exemestane groups and the tamoxifen group (mean +/- s.d., -0.21 +/- 0.92 vs -0.04 +/- 0.49, respectively, P = 0.71, effect size = -0.20), regardless of prior chemotherapy status, and adjusting for baseline characteristics. Conclusions: The Co-SOFT study, although limited by small samples size, provides no evidence that adding OFS to adjuvant oral endocrine therapy substantially affects global cognitive function.
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Regan, M. M.
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Ribi, K.
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Francis, P. A.
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Puglisi, F.
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Bellet, M.
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Spazzapan, S.
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Karlsson, Per,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xkperd
(author)
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Budman, D. R.
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Zaman, K.
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Abdi, E. A.
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Domchek, S. M.
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Feng, Y.
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Price, K. N.
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Coates, A. S.
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Gelber, R. D.
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Maruff, P.
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Boyle, F.
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Forbes, J. F.
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Ahles, T.
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Fleming, G. F.
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Bernhard, J.
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Co, Soft Investigators
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för onkologi
(creator_code:org_t)
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In:British Journal of Cancer: Springer Science and Business Media LLC114:9, s. 956-9640007-09201532-1827
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Phillips, K. A.
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Regan, M. M.
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Ribi, K.
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Francis, P. A.
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Puglisi, F.
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Bellet, M.
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Spazzapan, S.
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Karlsson, Per, 1 ...
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Budman, D. R.
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Zaman, K.
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Abdi, E. A.
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Domchek, S. M.
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Feng, Y.
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Price, K. N.
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Coates, A. S.
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Gelber, R. D.
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Maruff, P.
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Boyle, F.
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Forbes, J. F.
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Ahles, T.
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Fleming, G. F.
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Bernhard, J.
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Co, Soft Investi ...
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University of Gothenburg