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A randomized trial ...
A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans
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- Romu, Thobias (author)
- Linköpings universitet,Medicinsk informatik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Vavruch, C. (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Dahlqvist Leinhard, Olof (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Radiofysikavdelningen US
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- Tallberg, J. (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Dahlström, Nils (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Röntgenkliniken i Linköping
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- Persson, Anders (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Röntgenkliniken i Linköping
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- Heglind, Mikael, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.
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- Lidell, Martin, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.
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- Enerbäck, Sven, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.
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- Borga, Magnus (author)
- Linköpings universitet,Medicinsk informatik,Tekniska högskolan,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Nyström, Fredrik (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Endokrinmedicinska kliniken
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Metabolism-Clinical and Experimental. - : Elsevier BV. - 0026-0495 .- 1532-8600. ; 65:6, s. 926-934
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https://liu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Objective. To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze. Design. Randomized, open, parallel-group trial. Methods. Healthy non-selected participants were randomized to achieve cold-exposure 1 hour/day, or to avoid any sense of feeling cold, for 6 weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI). Results. Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841 +/- 199 kCal/24 h to 1795 +/- 213 kCal/24 h, p = 0.047 cold-activated MR from 1900 +/- 150 kCal/24 h to 1793 +/- 215 kCal/24 h, p = 0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p = 0.052). The difference between MR changes by the interventions between groups was statistically significant (p = 0.008 at room temperature, p = 0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported >= 8 days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175 +/- 0.015 1 to 0.0216 +/- 0.014 1, p = 0.049). Conclusions. We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Brown adipose tissue
- Cold exposure
- Magnetic resonance imaging
- Metabolic rate
- water-fat mri
- healthy humans
- adult humans
- identification
- metabolism
- Endocrinology & Metabolism
- Brown adipose tissue; Cold exposure; Magnetic resonance imaging; Metabolic rate
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Romu, Thobias
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Vavruch, C.
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Dahlqvist Leinha ...
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Tallberg, J.
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Dahlström, Nils
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Persson, Anders
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Heglind, Mikael, ...
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Lidell, Martin, ...
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Enerbäck, Sven, ...
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Borga, Magnus
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Nyström, Fredrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Metabolism-Clini ...
- By the university
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University of Gothenburg
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Linköping University