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  • Romu, ThobiasLinköpings universitet,Medicinsk informatik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV (author)

A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/237887
  • https://gup.ub.gu.se/publication/237887URI
  • https://doi.org/10.1016/j.metabol.2016.03.012DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128200URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies: Linkoping University; County Council of Ostergotland (LUA-ALF), Sweden; Swedish Research Council [2013-4466, 2012-1652, 2014-2516]; Knut and Alice Wallenberg Foundation; Sahlgrenskas University Hospital (LUA-ALF); European Union grant (DIABAT) [HEALTH-F2-
  • Objective. To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze. Design. Randomized, open, parallel-group trial. Methods. Healthy non-selected participants were randomized to achieve cold-exposure 1 hour/day, or to avoid any sense of feeling cold, for 6 weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI). Results. Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841 +/- 199 kCal/24 h to 1795 +/- 213 kCal/24 h, p = 0.047 cold-activated MR from 1900 +/- 150 kCal/24 h to 1793 +/- 215 kCal/24 h, p = 0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p = 0.052). The difference between MR changes by the interventions between groups was statistically significant (p = 0.008 at room temperature, p = 0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported >= 8 days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175 +/- 0.015 1 to 0.0216 +/- 0.014 1, p = 0.049). Conclusions. We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.

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  • Vavruch, C.Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten (author)
  • Dahlqvist Leinhard, OlofÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Radiofysikavdelningen US(Swepub:liu)oloda24 (author)
  • Tallberg, J.Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten (author)
  • Dahlström, NilsÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Röntgenkliniken i Linköping(Swepub:liu)nilda87 (author)
  • Persson, AndersÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Röntgenkliniken i Linköping(Swepub:liu)andpe75 (author)
  • Heglind, Mikael,1975Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.(Swepub:gu)xhegmi (author)
  • Lidell, Martin,1970Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.(Swepub:gu)xlidma (author)
  • Enerbäck, Sven,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.(Swepub:gu)xenesv (author)
  • Borga, MagnusLinköpings universitet,Medicinsk informatik,Tekniska högskolan,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)magbo72 (author)
  • Nyström, FredrikÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Endokrinmedicinska kliniken(Swepub:liu)freny92 (author)
  • Linköpings universitetMedicinsk informatik (creator_code:org_t)

Related titles

  • In:Metabolism-Clinical and Experimental: Elsevier BV65:6, s. 926-9340026-04951532-8600

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