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Gene Therapy Induce...
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis
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- Tengvall, Sara, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Eneljung, Tove, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Jirholt, Pernilla, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Turesson, Olof, 1986 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Wing, Kajsa, 1977 (author)
- Karolinska Institutet
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- Holmdahl, R. (author)
- Karolinska Institutet
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- Kihlberg, Jan (author)
- Uppsala universitet,Organisk kemi
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- Stern, Anna, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Mårtensson, Inga-Lill, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Henningsson, Louise, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Gustafsson, K. (author)
- UCL Inst Child Hlth, Mol & Cellular Immunol Sect, London, England.
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- Gjertsson, Inger, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
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(creator_code:org_t)
- 2016-05-09
- 2016
- English.
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In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 11:5
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https://doi.org/10.1...
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Abstract
Subject headings
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- Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, where only 5% of the mice developed arthritis as compared with 95% of the control mice. In the CII-tolerized mice, the proportion of Tregs as well as mRNA expression of SOCS1 (suppressors of cytokine signaling 1) increased at day 3 after CII immunization. Transfer of B cells or non-B cell APC, as well as T cells, from tolerized to naive mice all mediated a certain degree of tolerance. Thus, sustainable tolerance is established very early during the course of arthritis and is mediated by both B and non-B cells as APCs. This novel approach for inducing tolerance to disease specific antigens can be used for studying tolerance mechanisms, not only in CIA but also in other autoimmune diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- REGULATORY T-CELLS
- II COLLAGEN
- B-CELLS
- AUTOIMMUNE ARTHRITIS
- IMMUNE-RESPONSES
- DENDRITIC CELLS
- TRANSGENIC MICE
- SELF-TOLERANCE
- INDUCTION
- SUPPRESSION
Publication and Content Type
- ref (subject category)
- art (subject category)
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Plos One
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- By the author/editor
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Tengvall, Sara, ...
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Eneljung, Tove, ...
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Jirholt, Pernill ...
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Turesson, Olof, ...
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Wing, Kajsa, 197 ...
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Holmdahl, R.
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Kihlberg, Jan
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Stern, Anna, 198 ...
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Mårtensson, Inga ...
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Henningsson, Lou ...
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Gustafsson, K.
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Gjertsson, Inger ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Plos One
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet