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Gene Therapy Induce...
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Tengvall, Sara,1977Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
(author)
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-05-09
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Public Library of Science (PLoS),2016
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LIBRIS-ID:oai:gup.ub.gu.se/238562
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https://gup.ub.gu.se/publication/238562URI
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https://doi.org/10.1371/journal.pone.0154630DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298679URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133638895URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, where only 5% of the mice developed arthritis as compared with 95% of the control mice. In the CII-tolerized mice, the proportion of Tregs as well as mRNA expression of SOCS1 (suppressors of cytokine signaling 1) increased at day 3 after CII immunization. Transfer of B cells or non-B cell APC, as well as T cells, from tolerized to naive mice all mediated a certain degree of tolerance. Thus, sustainable tolerance is established very early during the course of arthritis and is mediated by both B and non-B cells as APCs. This novel approach for inducing tolerance to disease specific antigens can be used for studying tolerance mechanisms, not only in CIA but also in other autoimmune diseases.
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Eneljung, Tove,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xeneto
(author)
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Jirholt, Pernilla,1972Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xjirpe
(author)
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Turesson, Olof,1986Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
(author)
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Wing, Kajsa,1977Karolinska Institutet(Swepub:gu)xwingk
(author)
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Holmdahl, R.Karolinska Institutet
(author)
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Kihlberg, JanUppsala universitet,Organisk kemi(Swepub:uu)janki643
(author)
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Stern, Anna,1980Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
(author)
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Mårtensson, Inga-Lill,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xmalil
(author)
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Henningsson, Louise,1979Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xhenlo
(author)
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Gustafsson, K.UCL Inst Child Hlth, Mol & Cellular Immunol Sect, London, England.
(author)
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Gjertsson, Inger,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.(Swepub:gu)xgjein
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
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In:Plos One: Public Library of Science (PLoS)11:51932-6203
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