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  • Tengvall, Sara,1977Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden. (author)

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-05-09
  • Public Library of Science (PLoS),2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/238562
  • https://gup.ub.gu.se/publication/238562URI
  • https://doi.org/10.1371/journal.pone.0154630DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298679URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133638895URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, where only 5% of the mice developed arthritis as compared with 95% of the control mice. In the CII-tolerized mice, the proportion of Tregs as well as mRNA expression of SOCS1 (suppressors of cytokine signaling 1) increased at day 3 after CII immunization. Transfer of B cells or non-B cell APC, as well as T cells, from tolerized to naive mice all mediated a certain degree of tolerance. Thus, sustainable tolerance is established very early during the course of arthritis and is mediated by both B and non-B cells as APCs. This novel approach for inducing tolerance to disease specific antigens can be used for studying tolerance mechanisms, not only in CIA but also in other autoimmune diseases.

Subject headings and genre

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  • Eneljung, Tove,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xeneto (author)
  • Jirholt, Pernilla,1972Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xjirpe (author)
  • Turesson, Olof,1986Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden. (author)
  • Wing, Kajsa,1977Karolinska Institutet(Swepub:gu)xwingk (author)
  • Holmdahl, R.Karolinska Institutet (author)
  • Kihlberg, JanUppsala universitet,Organisk kemi(Swepub:uu)janki643 (author)
  • Stern, Anna,1980Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden. (author)
  • Mårtensson, Inga-Lill,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xmalil (author)
  • Henningsson, Louise,1979Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.(Swepub:gu)xhenlo (author)
  • Gustafsson, K.UCL Inst Child Hlth, Mol & Cellular Immunol Sect, London, England. (author)
  • Gjertsson, Inger,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.(Swepub:gu)xgjein (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)

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  • In:Plos One: Public Library of Science (PLoS)11:51932-6203

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