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Depression, anxiety...
Depression, anxiety, and antidepressant treatment in women: association with in vitro fertilization outcome
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- Cesta, C. E. (author)
- Karolinska Institutet
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- Viktorin, A. (author)
- Karolinska Institutet
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- Olsson, H. (author)
- Karolinska Institutet
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- Johansson, Viktoria (author)
- Karolinska Institutet
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- Sjolander, A. (author)
- Karolinska Institutet
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- Bergh, Christina, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Skalkidou, Alkistis (author)
- Uppsala universitet,Obstetrik & gynekologi,Obstetrik
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Nygren, K. G. (author)
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- Cnattingius, S. (author)
- Karolinska Institutet
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- Iliadou, A. N. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 105:6
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To investigate associations between depression, anxiety, and antidepressants before in vitro fertilization (1VF) and IVF cycle outcomes, including pregnancy, live birth, and miscarriage. Patient(s): Nulliparous women undergoing their first 1VF cycle recorded in the Swedish Quality Register of Assisted Reproduction, January 2007 to December 2012 (n = 23,557). Main Outcome Measure(s): Associations between diagnoses of depression/anxiety, antidepressants, and IVF cycle outcome evaluated using logistic regression to produce adjusted odds ratios (AOR) and 950/o confidence intervals (CI). Result(s): In total, 4.40/o of women had been diagnosed with depression/anxiety and/or dispensed antidepressants before their IVF first cycle. The odds for pregnancy and live birth were decreased (n = 1,044; AOR = 0.86; 950/0 CI, 0.75-0.98; and AOR = 0.83; 950/o CI, 0.720.96, respectively). For women with a prescription for a selective serotonin reuptake inhibitor (SSRI) only (n = 829), no statistically significant associations were found. Women with non-SSRI antidepressants (n = 52) were at reduced odds of pregnancy (AOR = 0.41; 950/0 CI, 0.21-0.80) and live birth (AOR = 0.27; 950/o CI, 0.11-0.68). Women with a depression/anxiety diagnosis with no antidepressant (n = 164) also had reduced odds of pregnancy (AOR = 0.58; 950/0 CI, 0.41-0.82) and live birth (AOR = 0.60; 95% CI, 0.41-0.89). Among the women who became pregnant (39.70/0, there were no statistically significant associations between exposure and miscarriage except for the women taking non-SSRI antidepressants (AOR = 3.56; 950/o CI, 1.06-11.9). Conclusion(s): A diagnosis of depression/anxiety and/or treatment with antidepressants before IVF was associated with slightly reduced odds of pregnancy and live birth. Women with the presence of depression/anxiety without antidepressants had a more pronounced reduction in odds, implying that the underlying disorder is important for the observed association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Antidepressants
- depression
- epidemiology
- in vitro fertilization
- IVF outcome
- serotonin reuptake inhibitors
- assisted reproductive technology
- quality-of-life
- psychiatric-disorders
- pharmacoepidemiologic research
- psychological stress
- spontaneous-abortion
- infertile women
- pregnancy
- metaanalysis
- Obstetrics & Gynecology
- Reproductive Biology
- Antidepressants; depression; epidemiology; in vitro fertilization; IVF outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cesta, C. E.
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Viktorin, A.
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Olsson, H.
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Johansson, Vikto ...
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Sjolander, A.
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Bergh, Christina ...
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show more...
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Skalkidou, Alkis ...
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Nygren, K. G.
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Cnattingius, S.
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Iliadou, A. N.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Fertility and St ...
- By the university
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University of Gothenburg
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Uppsala University
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Umeå University
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Karolinska Institutet