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Effects of 15 weeks...
Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia
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- Ernberg, M. (author)
- Karolinska Institutet
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- Christidis, N. (author)
- Karolinska Institutet
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- Ghafouri, Bijar (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Bileviciute-Ljungar, I. (author)
- Karolinska Institutet
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- Logren, M. (author)
- Karolinska Institute, Sweden; Danderyd Hospital, Sweden
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- Larsson, Anette, 1970 (author)
- Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för neurovetenskap och fysiologi,University of Gothenburg Centre for person-centred care (GPCC),Institute of Neuroscience and Physiology,University of Gothenburg, Sweden; University of Gothenburg, Sweden
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- Palstam, Annie, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg, Sweden,Sahlgrenska Academy, University of Gothenburg
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- Bjersing, Jan, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- Mannerkorpi, Kaisa, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg Centre for person-centred care (GPCC),University of Gothenburg, Sweden; University of Gothenburg, Sweden
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- Kosek, Eva (author)
- Karolinska Institutet
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- Gerdle, Björn (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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(creator_code:org_t)
- 2016-06-13
- 2016
- English.
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In: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 18
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Abstract
Subject headings
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- Background: This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON). Methods: Twenty-four female patients with FMS (54 +/- 8 years) and 27 female CON (54 +/- 9 years) were subjected to intramuscular microdialysis of the most painful vastus lateralis muscle before and after 15 weeks of progressive resistance exercise twice per week. Baseline dialysates were sampled in the resting muscle 140 min after insertion of the microdialysis catheter. The participants then performed repetitive dynamic contractions (knee extension) for 20 min, followed by 60 min rest. Pain intensity was assessed with a 0-100 mm visual analogue scale (VAS), and fatigue was assessed with Borg's RPE throughout microdialysis. Dialysates were sampled every 20 min and analyzed with Luminex for interleukin (IL)-1 beta, tumor necrosis factor (TNF) alpha, IL-6, and IL-8. Results: At both sessions and for both groups the dynamic contractions increased pain (P < 0.012) and fatigue (P < 0.001). The levels of TNF were lower in the FMS group than the CON group at both sessions (P < 0.05), but none of the other cytokines differed between the groups. IL-6 and IL-8 increased after the dynamic contractions in both groups (P < 0.010), while TNF increased only in CON (P < 0.05) and IL-1 beta did not change. Overall pain intensity was reduced after the 15 weeks of resistance exercise in FMS (P < 0.05), but there was no changes in fatigue or cytokine levels. Conclusion: Progressive resistance exercise for 15 weeks did not affect the interstitial levels of IL-1 beta, TNF, IL-6, and IL-8 in the vastus lateralis muscle of FMS patients or CON.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Cytokines
- Dynamic contractions
- Exercise
- Fibromyalgia
- Microdialysis
- Quadriceps
- chronic widespread pain
- human skeletal-muscle
- randomized
- controlled-trial
- trapezius muscle
- knee osteoarthritis
- physical
- function
- microdialysis
- women
- interleukin-6
- population
- Rheumatology
- Cytokines; Dynamic contractions; Exercise; Fibromyalgia; Microdialysis; Quadriceps
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ernberg, M.
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Christidis, N.
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Ghafouri, Bijar
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Bileviciute-Ljun ...
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Logren, M.
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Larsson, Anette, ...
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Palstam, Annie, ...
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Bjersing, Jan, 1 ...
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Mannerkorpi, Kai ...
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Kosek, Eva
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Gerdle, Björn
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Arthritis Resear ...
- By the university
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University of Gothenburg
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Linköping University
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Uppsala University
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Karolinska Institutet
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Högskolan Dalarna