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Mapping quantal tou...
Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation
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Panchuelo, R. M. S. (author)
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- Ackerley, Rochelle, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Glover, P. M. (author)
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Bowtell, R. W. (author)
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- Wessberg, Johan, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Francis, S. T. (author)
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McGlone, F. (author)
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(creator_code:org_t)
- 2016
- 2016
- English.
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In: Elife. - 2050-084X. ; 5
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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Abstract
Subject headings
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- Using ultra-high field 7 Tesla (7T) functional magnetic resonance imaging (fMRI), we map the cortical and perceptual responses elicited by intraneural microstimulation (INMS) of single mechanoreceptive afferent units in the median nerve, in humans. Activations are compared to those produced by applying vibrotactile stimulation to the unit's receptive field, and unit-type perceptual reports are analyzed. We show that INMS and vibrotactile stimulation engage overlapping areas within the topographically appropriate digit representation in the primary somatosensory cortex. Additional brain regions in bilateral secondary somatosensory cortex, premotor cortex, primary motor cortex, insula and posterior parietal cortex, as well as in contralateral prefrontal cortex are also shown to be activated in response to INMS. The combination of INMS and 7T fMRI opens up an unprecedented opportunity to bridge the gap between first-order mechanoreceptive afferent input codes and their spatial, dynamic and perceptual representations in human cortex.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- primary somatosensory cortex
- median nerve-stimulation
- false discovery
- rate
- human hand
- cutaneous mechanoreceptors
- thalamocortical axons
- cerebral-cortex
- glabrous skin
- fmri
- representation
- Life Sciences & Biomedicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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