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- Blomster, Juuso I.Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)
Coronary flow reserve as a link between exercise capacity, cardiac systolic and diastolic function
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- Elsevier BV,2016
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- LIBRIS-ID:oai:gup.ub.gu.se/239977
- https://gup.ub.gu.se/publication/239977URI
- https://doi.org/10.1016/j.ijcard.2016.04.179DOI
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- Language:English
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Notes
- Background: Decreased coronary flow reserve (CFR) is associated with increased risk of adverse cardiovascular events. We sought to investigate how CFR from left anterior descending (LAD) coronary artery reflects clinical markers of cardiac function. Methods: We enrolled 400 patients referred for myocardium perfusion scintigraphy due to chest pain at Sahlgrenska University Hospital in Gothenburg, Sweden. Transthoracic echocardiography including adenosine-assisted CFR in LAD was performed at a separate occasion. Results: Median age was 62 years (range 32-83) and 47% were female. Prior myocardial infarction had occurred in 28% of the population. In adjusted multivariate models, CFR in LAD was associated with echocardiography left ventricle ejection fraction at rest (beta = 0.97, p = 0.033) as well as under stress (beta = 1.52, p = 0.0056) and maximum exercise capacity (beta = 6.27, p = 0.026). CFR in LAD outweighed left ventricle ejection fraction as the determinant of maximum exercise capacity. Hyperaemic diastolic mitral annulus peak velocity measured by vector velocity imaging was inversely associated with LAD CFR (beta = -0.39, p = 0.0077). In subgroup analyses these findings were associated with normal coronary perfusion in myocardium perfusion scintigraphy. Conclusions: In patients with angina-like symptoms CFR measured in LAD reflects well both systolic and diastolic cardiac function emphasizing the essential role of myocardial microvascular circulation in cardiac physiology. (C) 2016 Published by Elsevier Ireland Ltd.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Cardiac imaging
- Systolic function
- Diastolic function
- Echocardiography
- Coronary flow reserve
- preserved ejection fraction
- ischemic-heart-disease
- artery-disease
- microvascular dysfunction
- vascular dysfunction
- diabetes-mellitus
- prognostic value
- blood-flow
- abnormalities
- association
Added entries (persons, corporate bodies, meetings, titles ...)
- Svedlund, SaraGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsveds (author)
- Utkovic Westergren, HelenaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xwehel (author)
- Gan, Li-Ming,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xganli (author)
- Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)
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- In:International Journal of Cardiology: Elsevier BV217, s. 161-1660167-5273
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