A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.

Primary biliary cholangitis (formerly called primary biliary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients with this disease.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Adult
Aged
Alkaline Phosphatase
blood
Bile Acids and Salts
blood
Bone Density
drug effects
Chenodeoxycholic Acid
adverse effects
analogs & derivatives
therapeutic use
Double-Blind Method
Female
Fibroblast Growth Factors
blood
Humans
Liver Cirrhosis
etiology
Liver Cirrhosis
Biliary
blood
complications
drug therapy
Male
Middle Aged
Pruritus
chemically induced

Andreone, Pietro (author)
Mazzella, Giuseppe (author)
Strasser, Simone I (author)
Bowlus, Christopher (author)
Invernizzi, Pietro (author)
Drenth, Joost P H (author)
Pockros, Paul J (author)
Regula, Jaroslaw (author)
Beuers, Ulrich (author)
Trauner, Michael (author)
Jones, David E (author)
Floreani, Annarosa (author)
Hohenester, Simon (author)
Luketic, Velimir (author)
Shiffman, Mitchell (author)
van Erpecum, Karel J (author)
Vargas, Victor (author)
Vincent, Catherine (author)
Hirschfield, Gideon M (author)
Shah, Hemant (author)
Hansen, Bettina (author)
Lindor, Keith D (author)
Marschall, Hanns-Ulrich,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xmarsh (author)
Kowdley, Kris V (author)
Hooshmand-Rad, Roya (author)
Marmon, Tonya (author)
Sheeron, Shawn (author)
Pencek, Richard (author)
MacConell, Leigh (author)
Pruzanski, Mark (author)
Shapiro, David (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

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