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Diagnosing Dementia...
Diagnosing Dementia in the Clinical Setting: Can Amyloid PET Provide Additional Value Over Cerebrospinal Fluid?
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Weston, Philip S J (author)
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Paterson, Ross W (author)
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Dickson, John (author)
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Barnes, Anna (author)
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Bomanji, Jamshed B (author)
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Kayani, Irfan (author)
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Lunn, Michael P (author)
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Mummery, Catherine J (author)
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Warren, Jason D (author)
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Rossor, Martin N (author)
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Fox, Nick C (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, Jonathan M (author)
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(creator_code:org_t)
- 2016
- 2016
- English.
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In: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 54:4, s. 1297-1302
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Abstract
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- Cerebrospinal fluid (CSF) measures of amyloid and tau are the first-line Alzheimer's disease biomarkers in many clinical centers. We assessed if and when the addition of amyloid PET following CSF measurements provides added diagnostic value. Twenty patients from a cognitive clinic, who had undergone detailed assessment including CSF measures, went on to have amyloid PET. The treating neurologist's working diagnosis, and degree of diagnostic certainty, was assessed both before and after the PET. Amyloid PET changed the diagnosis in 7/20 cases. Amyloid PET can provide added diagnostic value, particularly in young-onset, atypical dementias, where CSF results are borderline and diagnostic uncertainty remains.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Weston, Philip S ...
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Paterson, Ross W
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Dickson, John
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Barnes, Anna
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Bomanji, Jamshed ...
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Kayani, Irfan
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show more...
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Lunn, Michael P
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Mummery, Catheri ...
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Warren, Jason D
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Rossor, Martin N
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Fox, Nick C
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Zetterberg, Henr ...
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Schott, Jonathan ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Alzhe ...
- By the university
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University of Gothenburg