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Role of JNK activat...
Role of JNK activation in pancreatic β-cell death by streptozotocin
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Cheon, Hwanju (author)
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Cho, Jae Min (author)
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Kim, Sunshin (author)
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show more...
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Baek, Seung-Hoon (author)
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Lee, Moon-Kyu (author)
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Kim, Kwang-Won (author)
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Yu, Seong-Woon (author)
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- Solinas, Giovanni (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Kim, Soung Soo (author)
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Lee, Myung-Shik (author)
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show less...
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Molecular and Cellular Endocrinology. - 0303-7207. ; 321:2, s. 131-137
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- c-Jun N-terminal kinase (JNK) is activated by cellular stress and plays critical roles in diverse types of cell death. However, role of JNK in β-cell injury is obscure. We investigated the role for JNK in streptozotocin (STZ)-induced β-cell death. STZ induced JNK activation in insulinoma or islet cells. JNK inhibitors attenuated insulinoma or islet cell death by STZ. STZ-induced JNK activation was decreased by PARP inhibitors, suggesting that JNK activation is downstream of PARP-1. Phosphatase inhibitors induced activation of JNK and abrogated the suppression of STZ-induced JNK activation by PARP inhibitors, suggesting that the inhibition of phosphatases is involved in the activation of JNK by STZ. STZ induced production of reactive oxygen species (ROS) as potential inhibitors of phosphatases, which was suppressed by PARP inhibitors. PARP-1 siRNA attenuated insulinoma cell death and JNK activation after STZ treatment, which was reversed by MKP (MAP kinase phosphatase)-1 siRNA. These results suggest that JNK is activated by STZ downstream of PARP-1 through inactivation of phosphatases such as MKP, which plays important roles in STZ-induced β-cell death.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- JNK
- beta-cells
- Insulin
- Diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cheon, Hwanju
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Cho, Jae Min
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Kim, Sunshin
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Baek, Seung-Hoon
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Lee, Moon-Kyu
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Kim, Kwang-Won
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show more...
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Yu, Seong-Woon
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Solinas, Giovann ...
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Kim, Soung Soo
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Lee, Myung-Shik
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Molecular and Ce ...
- By the university
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University of Gothenburg