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Asymmetric Inherita...
Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions
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- Hill, Sandra Malmgren, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology
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- Hao, Xinxin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Institutionen för biomedicin,Department of Chemistry and Molecular Biology,Institute of Biomedicine
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- Grönvall, Johan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Spikings-Nordby, Stephanie (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Widlund, Per O (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology
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Amen, T. (author)
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- Jorhov, Anna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Josefson, Rebecca (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology
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Kaganovich, D. (author)
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- Liu, Beidong, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Nyström, Thomas, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 16:3, s. 826-838
- Related links:
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Age can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs) that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered a previously unknown role for endocytosis, vacuole fusion, and the myosin-dependent adaptor protein Vac17 in asymmetrical inheritance of misfolded proteins. Overproduction of Vac17 increases deposition of aggregates into cytoprotective vacuole-associated sites, counteracts age-related breakdown of endocytosis and vacuole integrity, and extends replicative lifespan. The link between damage asymmetry and vesicle trafficking can be explained by a direct interaction between aggregates and vesicles. We also show that the protein disaggregase Hsp104 interacts physically with endocytic vesicle-associated proteins, such as the dynamin-like protein, Vps1, which was also shown to be required for Vac17-dependent sequestration of protein aggregates. These data demonstrate that two physiognomies of aging-reduced endocytosis and protein aggregation-are interconnected and regulated by Vac17.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- life-span
- saccharomyces-cerevisiae
- damaged proteins
- misfolded
- proteins
- actin cytoskeleton
- quality-control
- budding yeast
- v-atpase
- fusion
- chaperone
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Hill, Sandra Mal ...
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Hao, Xinxin
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Grönvall, Johan
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Spikings-Nordby, ...
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Widlund, Per O
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Amen, T.
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show more...
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Jorhov, Anna
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Josefson, Rebecc ...
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Kaganovich, D.
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Liu, Beidong, 19 ...
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Nyström, Thomas, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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University of Gothenburg