Search: onr:"swepub:oai:gup.ub.gu.se/242393" >
Asymmetric Inherita...
-
Hill, Sandra Malmgren,1987Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology
(author)
Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions
- Article/chapterEnglish2016
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/242393
-
https://gup.ub.gu.se/publication/242393URI
-
https://doi.org/10.1016/j.celrep.2016.06.016DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Age can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs) that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered a previously unknown role for endocytosis, vacuole fusion, and the myosin-dependent adaptor protein Vac17 in asymmetrical inheritance of misfolded proteins. Overproduction of Vac17 increases deposition of aggregates into cytoprotective vacuole-associated sites, counteracts age-related breakdown of endocytosis and vacuole integrity, and extends replicative lifespan. The link between damage asymmetry and vesicle trafficking can be explained by a direct interaction between aggregates and vesicles. We also show that the protein disaggregase Hsp104 interacts physically with endocytic vesicle-associated proteins, such as the dynamin-like protein, Vps1, which was also shown to be required for Vac17-dependent sequestration of protein aggregates. These data demonstrate that two physiognomies of aging-reduced endocytosis and protein aggregation-are interconnected and regulated by Vac17.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Hao, XinxinGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Institutionen för biomedicin,Department of Chemistry and Molecular Biology,Institute of Biomedicine(Swepub:gu)xxinha
(author)
-
Grönvall, JohanGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
(author)
-
Spikings-Nordby, StephanieGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
(author)
-
Widlund, Per OGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology(Swepub:gu)xwidlp
(author)
-
Amen, T.
(author)
-
Jorhov, AnnaGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
(author)
-
Josefson, RebeccaGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology(Swepub:gu)xlinre
(author)
-
Kaganovich, D.
(author)
-
Liu, Beidong,1972Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xbeili
(author)
-
Nyström, Thomas,1960Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology(Swepub:gu)xnysth
(author)
-
Göteborgs universitetInstitutionen för biomedicin
(creator_code:org_t)
Related titles
-
In:Cell Reports: Elsevier BV16:3, s. 826-8382211-1247
Internet link
Find in a library
To the university's database
- By the author/editor
-
Hill, Sandra Mal ...
-
Hao, Xinxin
-
Grönvall, Johan
-
Spikings-Nordby, ...
-
Widlund, Per O
-
Amen, T.
-
show more...
-
Jorhov, Anna
-
Josefson, Rebecc ...
-
Kaganovich, D.
-
Liu, Beidong, 19 ...
-
Nyström, Thomas, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Cell Reports
- By the university
-
University of Gothenburg