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Nitric oxide syntha...
Nitric oxide synthase inhibition blocks phencyclidine-induced behavioural effects on prepulse inhibition and locomotor activity in the rat.
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Johansson, C (author)
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Jackson, D M (author)
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- Svensson, Lennart, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology
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(creator_code:org_t)
- 1997
- 1997
- English.
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In: Psychopharmacology. - 0033-3158. ; 131:2, s. 167-73
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- The ability of the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), to block the behavioural effects of the potent psychotomimetic, phencyclidine, was tested in rats using two different behavioural models. L-NAME was found to block both phencyclidine-induced disruption of prepulse inhibition of acoustic startle and phencyclidine-induced stimulation of locomotor activity. A selective action of L-NAME on the effects of phencyclidine was indicated, since L-NAME did not alter the effects of amphetamine, another potent psychotomimetic, in these behavioural models. These observations suggest that a nitric oxide-dependent mechanism may be involved in the effects of phencyclidine in the central nervous system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Animals
- Behavior
- Animal
- drug effects
- Dose-Response Relationship
- Drug
- Enzyme Inhibitors
- pharmacology
- Locomotion
- drug effects
- Male
- NG-Nitroarginine Methyl Ester
- pharmacology
- Nitric Oxide Synthase
- drug effects
- Phencyclidine
- pharmacology
- Rats
- Rats
- Sprague-Dawley
- Reflex
- Startle
- drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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