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  • Karlsson, Lena,1964Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)

Risk of Recurrent Stroke in Patients with Symptomatic Mild (20-49% NASCET) Carotid Artery Stenosis

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016

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  • LIBRIS-ID:oai:gup.ub.gu.se/243338
  • https://gup.ub.gu.se/publication/243338URI
  • https://doi.org/10.1016/j.ejvs.2016.05.014DOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: The objective of this study was to evaluate the risk of recurrent ischaemic stroke in patients with ultrasound assessed symptomatic mild carotid artery stenosis (20-49% NASCET) treated solely with modern medical treatment. Method: This was a retrospective, observational register cohort study. Three groups of patients were recruited from a database of all carotid Doppler ultrasound examinations performed in the Gothenburg region between 2004 and 2009. Patients with symptomatic mild carotid artery stenosis (n = 162) were compared with patients with asymptomatic carotid artery stenosis (n = 301) of equal degree and a group of patients with surgically (CEA) treated symptomatic moderate or severe carotid artery stenosis (n = 220). Kaplan-Meier estimates and Cox proportional hazard models were used to compare the primary outcome (ipsilateral ischaemic stroke) between groups. Results: After a 3 year follow up, the cumulative incidence of recurrent ipsilateral stroke in patients with symptomatic mild carotid artery stenosis was 7.4%. Patients with symptomatic mild carotid artery stenosis had a substantially increased risk of recurrent ipsilateral stroke compared with asymptomatic patients with equal degree of stenosis (HR 5.5. 95% CI 1.8-17.1; p = .003) as also compared with patients with CEA treated symptomatic moderate or severe stenosis (HR 7.8. 95% CI 1.62-37.8; p = .011). Conclusions: The present study on patients with symptomatic mild carotid artery stenosis, as determined by Doppler ultrasound, shows that there is still a substantial risk of recurrent stroke in this group. (C) 2016 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

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  • Kangefjärd, ElisabethGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)
  • Hermansson, S.Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)
  • Strömberg, SGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)
  • Österberg, Klas,1966Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xostkl (author)
  • Nordanstig, AGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation (author)
  • Ryndel, Mikael,1982Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xrynmi (author)
  • Gellerman, KarlGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)
  • Fredén Lindqvist, JohanGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine (author)
  • Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xbgort (author)
  • Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Related titles

  • In:European Journal of Vascular and Endovascular Surgery: Elsevier BV52:3, s. 287-2941078-5884

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