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World Workshop on O...
World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction
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Villa, A. (author)
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Wolff, A. (author)
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Narayana, N. (author)
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Dawes, C. (author)
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Aframian, D. J. (author)
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Lynge Pedersen, A. M. (author)
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Vissink, A. (author)
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Aliko, A. (author)
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Sia, Y. W. (author)
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Joshi, R. K. (author)
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McGowan, R. (author)
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Jensen, S. B. (author)
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Kerr, A. R. (author)
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- Ekström, Jörgen, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Proctor, G. (author)
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(creator_code:org_t)
- 2016-01-20
- 2016
- English.
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In: Oral Diseases. - : Wiley. - 1354-523X. ; 22:5, s. 365-382
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https://doi.org/10.1...
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Abstract
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- The aim of this paper was to perform a systematic review of the pathogenesis of medication-induced salivary gland dysfunction (MISGD). Review of the identified papers was based on the standards regarding the methodology for systematic reviews set forth by the World Workshop on Oral Medicine IV and the PRISMA statement. Eligible papers were assessed for both the degree and strength of relevance to the pathogenesis of MISGD as well as on the appropriateness of the study design and sample size. A total of 99 papers were retained for the final analysis. MISGD in human studies was generally reported as xerostomia (the sensation of oral dryness) without measurements of salivary secretion rate. Medications may act on the central nervous system (CNS) and/or at the neuroglandular junction on muscarinic, α-and β-adrenergic receptors and certain peptidergic receptors. The types of medications that were most commonly implicated for inducing salivary gland dysfunction were those acting onthe nervous, cardiovascular, genitourinary, musculoskeletal, respiratory, and alimentary systems. Although many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
Keyword
- pathogenesis
- physiology
- saliva
- salivary glands
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Villa, A.
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Wolff, A.
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Narayana, N.
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Dawes, C.
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Aframian, D. J.
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Lynge Pedersen, ...
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show more...
-
Vissink, A.
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Aliko, A.
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Sia, Y. W.
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Joshi, R. K.
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McGowan, R.
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Jensen, S. B.
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Kerr, A. R.
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Ekström, Jörgen, ...
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Proctor, G.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Social and Clini ...
- Articles in the publication
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Oral Diseases
- By the university
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University of Gothenburg