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Diagnostic potential of tumor DNA from ovarian cyst fluid
- Wang, Y. X. (author)
-
- Sundfeldt, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Mateoiu, Constantina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
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- Shih, I. M. (author)
- Kurman, R. J. (author)
- Schaefer, J. (author)
- Silliman, N. (author)
- Kinde, I. (author)
- Springer, S. (author)
- Foote, M. (author)
- James, N. (author)
- Kinzler, K. W. (author)
- Papadopoulos, N. (author)
- Diaz, L. A. (author)
- Vogelstein, B. (author)
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- (creator_code:org_t)
- 2016
- 2016
- English.
- In: Elife. - 2050-084X. ; 5
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or nonneoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- FINE-NEEDLE-ASPIRATION
- GRADE SEROUS CARCINOMA
- PANCREATIC-CANCER
- LAPAROSCOPIC MANAGEMENT
- BRAF MUTATIONS
- ADNEXAL CYSTS
- BIOPSY
- SURVIVAL
- WOMEN
- ULTRASONOGRAPHY
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Kurman, R. J.
- Schaefer, J.
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- Silliman, N.
- Kinde, I.
- Springer, S.
- Foote, M.
- Kristjansdottir, ...
- James, N.
- Kinzler, K. W.
- Papadopoulos, N.
- Diaz, L. A.
- Vogelstein, B.
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