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Exercise and nutrit...
Exercise and nutritional benefits in PD: Rodent models and clinical settings
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- Archer, Trevor, 1949 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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Kostrzewa, R. M. (author)
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(creator_code:org_t)
- 2016-01-05
- 2016
- English.
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In: Current Topics in Behavioral Neurosciences. - Cham : Springer International Publishing. - 1866-3370. ; 29, s. 333-351
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Abstract
Subject headings
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- Physical exercise offers a highly effective health-endowering activity as has been evidence using rodent models of Parkinson’s disease (PD). It is a particularly useful intervention in individuals employed in sedentary occupations or afflicted by a neurodegenerative disorder, such as PD. The several links between exercise and quality-of-life, disorder progression and staging, risk factors and symptoms-biomarkers in PD all endower a promise for improved prognosis. Nutrition provides a strong determinant for disorder vulnerability and prognosis with fish oils and vegetables with a mediterranean diet offering both protection and resistance. Three factors determining the effects of exercise on disorder severity of patients may be presented: (i) Exercise effects upon motor impairment, gait, posture and balance, (ii) Exercise reduction of oxidative stress, stimulation of mitochondrial biogenesis and up-regulation of autophagy, and (iii) Exercise stimulation of dopamine (DA) neurochemistry and trophic factors. Running-wheel performance, as measured by distance run by individual mice from different treatment groups, was related to DA-integrity, indexed by striatal DA levels. Finally, both nutrition and exercise may facilitate positive epigenetic outcomes, such as lowering the dosage of L-Dopa required for a therapeutic effect. © Springer International Publishing Switzerland 2015.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Amelioration
- Dopamine
- Epigenetics
- Exercise
- Impairment
- Nutrition
- Parkinson’s disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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