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Antibiotic-mediated...
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice
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Livanos, A. E. (author)
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- Greiner, Thomas U., 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Vangay, P. (author)
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Pathmasiri, W. (author)
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Stewart, D. (author)
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McRitchie, S. (author)
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Li, H. (author)
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Chung, J. (author)
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Sohn, J. (author)
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Kim, S. (author)
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Gao, Z. (author)
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Barber, C. (author)
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Kim, J. (author)
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Ng, S. (author)
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Rogers, A. B. (author)
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Sumner, S. (author)
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Zhang, X. S. (author)
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Cadwell, K. (author)
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Knights, D. (author)
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Alekseyenko, A. (author)
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Blaser, M. J. (author)
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(creator_code:org_t)
- 2016-08-22
- 2016
- English.
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In: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 1
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life, mimicking childhood exposures. We found that in mice receiving PAT, T1D incidence was significantly higher, and microbial community composition and structure differed compared with controls. In pre-diabetic male PAT mice, the intestinal lamina propria had lower Th17 and T reg proportions and intestinal SAA expression than in controls, suggesting key roles in transducing the altered microbiota signals. PAT affected microbial lipid metabolism and host cholesterol biosynthetic gene expression. These findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating T1D onset in non-obese diabetic mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- REGULATORY T-CELLS; EARLY-LIFE; NOD MICE; INTESTINAL MICROBIOTA; CHILDHOOD ASTHMA; CESAREAN-SECTION; GENE-EXPRESSION; INCREASED RISK; MOUSE MODEL; DIFFERENTIATION
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Livanos, A. E.
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Greiner, Thomas ...
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Vangay, P.
-
Pathmasiri, W.
-
Stewart, D.
-
McRitchie, S.
-
show more...
-
Li, H.
-
Chung, J.
-
Sohn, J.
-
Kim, S.
-
Gao, Z.
-
Barber, C.
-
Kim, J.
-
Ng, S.
-
Rogers, A. B.
-
Sumner, S.
-
Zhang, X. S.
-
Cadwell, K.
-
Knights, D.
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Alekseyenko, A.
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Bäckhed, Fredrik ...
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Blaser, M. J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
- Articles in the publication
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Nature Microbiol ...
- By the university
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University of Gothenburg